Endometriosis-associated intestinal tumors:A clinical and pathological study of 6 cases with a review of the literature

R E Slavin, Richard E. Slavin, Slavin RE, Krum R, R Krum, Robert Krum, Tung Van Dinh, T Van Dinh, Van Dinh T
Human pathology · 2000 · vol. 31(4) , pp. 456–463 · doi:10.1053/hp.2000.6712 · PMID:10821493 · W1973580176
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This clinical and pathological study examines six cases of endometriosis-associated intestinal tumors and reviews the relevant literature to understand their characteristics.

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Abstract

This clinicopathologic study of primary Mullerian tumors of the bowel arising in foci of endometriosis is based on six new cases and an analysis of 17 previously reported cases. Varieties of Mullerian tumors occur in the bowel; the most common types are endometrioid carcinoma, followed by various mixed Mullerian tumors and stromal sarcomas. Seventy-eight percent develop in the rectosigmoid colon, the remaining in the cecum or ileum. Those in the latter area tend to be sarcomas or mixed Mullerian tumors. Certain architectural growth characteristics, derived from precursor endometriosis, are common to most endometriosis-associated intestinal tumors (EAITs). Seventy percent of EAITs occur in the outer bowel wall. Transmural tumors tend to form luminal polyps and assume an hourglass shape. Metachronous or synchronous Mullerian tumors occur in 39% of cases. Seventy percent of women with EAITs are in their mid 30s to early 50s. Common presenting symptoms are abdominal or pelvic pain, melena, and an abdominal or pelvic mass. Documented in 26% of patients is a history of prolonged unopposed estrogen therapy. Only 28.5% of cases die of their tumors, but follow-up is less than 5 years in all but 2 patients.

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Condition tags

endometriosis

MeSH descriptors

Colorectal Neoplasms Endometriosis Mixed Tumor, Mullerian Neoplasms, Multiple Primary Uterine Neoplasms Adenofibroma Adenofibroma Adenosarcoma Adenosarcoma Adult Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinosarcoma Carcinosarcoma Colorectal Neoplasms Endometriosis Estrogen Replacement Therapy Estrogen Replacement Therapy Estrogens Estrogens

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

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License: CC0 · commercial use OK