Clear Cell Adenocarcinoma of the Colon Arising in the Background of Endometriosis: A Case Report and Diagnostic Approach

Alexander Finkelstein, Gillian H. Levy, Pei Hui
In: Laboratory Medicine · 2010 · vol. 41(2) , pp. 111–114 · doi:10.1309/lmjctyeh9s22vqxw · W2123562681
article OA: bronze CC0 ⤵ 4 in-corpus citations
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This report details a case of clear cell adenocarcinoma of the colon arising from endometriosis, confirmed by immunohistochemistry showing dysplastic clear cell changes within endometriotic glands and stroma.

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Abstract

Clear cell adenocarcinoma of the colon is rare, with only a handful of cases reported in the literature. Some of these cases are attributed to endometriotic involvement of the colonic wall; however, a presence of the clear cell adenocarcinoma and endometriotic glands with dysplastic clear cell changes in the colonic wall has not been compellingly demonstrated. We describe a case of clear cell adenocarcinoma of rectosigmoid in a 41-year-old woman, where we have been able to document endometriotic glands with dysplastic clear cell transformation in the background. The presence of the endometriotic glands and the endometrial stroma is confirmed with immunohistochemical stains. The diagnostic approach and immuhistochemical characteristics of these neoplasms are discussed along with difficulties in staging of these tumors.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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