Malignancy arising in endometriosis associated with unopposed estrogen replacement.
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Two cases of malignancy arising in dormant endometriosis after hysterectomy and estrogen replacement suggest progestins may reduce this risk.
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Abstract
Malignant transformation of endometriosis is a well documented phenomenon. Although it occurs most commonly in the ovaries, there have been approximately 50 reported cases of extraovarian malignant transformation of endometriosis. This paper presents two cases of malignancy arising from a dormant focus of endometriosis after total abdominal hysterectomy, bilateral salpingo-oophorectomy, and exogenous estrogen replacement therapy. These malignancies are often well differentiated and may behave similarly to estrogen-induced endometrial carcinomas. After surgical castration of a premenopausal woman with endometriosis, the use of progestins in replacement therapy may reduce the risk of malignancy arising in endometriosis.
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Cited by (49)
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- Topical estrogens for the treatment of superficial dyspareunia related to genitourinary syndrome of menopause in women with a history of endometriosis: A clinical dilemma 2023
- Atypical endometriosis: a review of an incompletely understood putative precursor of endometriosis-associated ovarian carcinoma 2023
- Malignant transformation of endometriosis in a laparoscopic trocar site a case report 2022
- Endometriosis in Peri- and Postmenopausal Year 2022
- Endometriosis 2021
- Malignant Transformation of Postmenopausal Endometriosis: A Systematic Review of the Literature 2021
- Clear Cell Carcinoma on an Endometriotic Nodule of The Recto-Vaginal Septum: Case Report 2021
- Mixed endometrioid and clear cell carcinoma arising from laparoscopic trocar site endometriosis 2019
- The management of menopause in women with a history of endometriosis: a systematic review 2017
- Malignant Transformation of Vaginal Endometriosis - A Review of Literature 2016
- Endometriosis and Cancer: Is There an Association? 2015
- Intestinal Obstruction due to Endometriosis Involving Atypical Hyperplasia: A Case Report 2015
- Bowel Endometriosis: An Overview 2014
- Müllerian Carcinosarcoma Arising From Intestinal Endometriosis 2013
- Endometriosis 2012
- Malignant Tumors of the Female Pelvic Floor: Imaging Features That Determine Therapy: <i>Pictorial Review</i> 2011
- Carcinoma of müllerian origin presenting as colorectal cancer: a clinicopathologic study of 13 Cases 2010
- Endometrioid Adenocarcinoma Arising from Endometriosis of the Uterine Cervix: A Case Report 2009
- Ovarian cancer in endometriosis: molecular biology, pathology, and clinical management 2009
- Endometriosis 2009
- Endometriosis related to family history of malignancies in the Yale series 2009
- Endometriosis 2007
- Endometrioid adenocarcinoma of the ovary arising from endometriosis and presenting as an acute abdomen 2007
- Hormone replacement therapy in women with past history of endometriosis 2006
- An Unusual Rectosigmoid Mass: Endometrioid Adenocarcinoma Arising in Colonic Endometriosis: Case Report and Literature Review 2005
- Malignant extraovarian endometriosis: A review 2005
- Endométriose extraovarienne dégénérée : à propos de trois cas et revue de la littérature 2004
- Endometriosis-Associated Ovarian Cancer: A Clinicopathologic Review 2004
- Hepatic endometriosis: A case report and review of the literature 2003
- Endometrial Adenocarcinoma Arising from Endometriosis of the Rectosigmoid Colon 2002
- Ovarian and extraovarian endometriosis-associated cancer 2002
- Primary endometrioid adenocarcinoma of the large intestine arising in colorectal endometriosis 2002
- Neoplastic and Pre-Neoplastic Changes in Gastrointestinal Endometriosis 2000
- Endometriosis-associated intestinal tumors:A clinical and pathological study of 6 cases with a review of the literature 2000
- Endometrioid carcinoma arising in pericecal endometriosis clinically mimicking Crohn's disease 2000
- Malignancies arising in endometriosis 1999
- Extraovarian Endometrioid Carcinoma Associated with Unopposed Oestrogen Replacement Therapy 1998
- Adenocarcinoma arising in extragonadal endometriosis 1998
- Endometrial stromal sarcoma arising in pelvic endometriosis in a patient receiving unopposed oestrogen therapy 1996
- Malignant tumors arising in endometriosis: clinical-pathological study and flow cytometry analysis 1996
- Endometriosis and atypical complex hyperplasia associated with unopposed oestrogen therapy 1994
- Diseases of the Peritoneum 1994
- Endometriosis 1993
- The role of definitive surgery and hormone replacement therapy in the treatment of endometriosis 1991
- Clear cell carcinoma of the inguinal region arising from endometriosis 1991
- Menses due to endometriosis in a woman following hysterectomy 1990
- Endometrioid stromal sarcomas arising from ovarian and extraovarian endometriosis: Report of two cases and review of the literature 1990
- Pathology of endometriosis. 1990
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