Extraovarian Endometrioid Carcinoma Associated with Unopposed Oestrogen Replacement Therapy

S Sidhu, Sidhu S, Sandeep Singh Sidhu, Edwards L, L Edwards, Lindsay A. Edwards, Rainer Stange, Rainer S, S Rainer, O'Connor T, Terence W. O'Connor, T O'connor
The Australian & New Zealand journal of obstetrics & gynaecology · 1998 · vol. 38(1) , pp. 125–127 · doi:10.1111/j.1479-828x.1998.tb02981.x · PMID:9521415 · W2024089699
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This case report describes a woman with endometriosis who developed extraovarian endometrioid carcinoma after prolonged unopposed estrogen therapy following hysterectomy and bilateral oophorectomy.

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Abstract

EDITORIAL COMMENT: We accepted this case report for publication because, apart from being interesting, it raises the question of the appropriate hormone replacement therapy after bilateral oophorectomy (usually with hysterectomy) has been performed when there is evidence of endometriosis. Menopausal symptoms in these women can be relieved by oestrogen therapy without return of pelvic pain or dyspareunia. The authors report a case of endometrial‐like carcinoma in a woman with known endometriosis after a hysterectomy and prolonged unopposed oestrogen therapy. Although this is a solitary case report, the authors explain that there are 8 others in the literature where malignancy occurred in extraovarian endometriosis after bilateral oophorectomy associated with unopposed oestrogen. One of our reviewers commented that a combination of oestrogen and progestogen should always be considered when prescribing hormone replacement therapy in women with a known history of endometriosis, following total hysterectomy and bilateral oophorectomy.

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Condition tags

endometriosisdyspareunia

MeSH descriptors

Carcinoma, Endometrioid Estrogen Replacement Therapy Estrogens, Conjugated (USP) Pelvic Neoplasms Carcinoma, Endometrioid Carcinoma, Endometrioid Contraindications Endometriosis Endometriosis Endometriosis Estrogen Replacement Therapy Estrogens, Conjugated (USP) Female Humans Hysterectomy Middle Aged Ovariectomy Pelvic Neoplasms Pelvic Neoplasms Postoperative Complications

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (2)

Source provenance

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License: CC0 · commercial use OK