Malignancy arising in extragonadal endometriosis.A case report and summary of the world literature

Brooks JJ, J J Brooks, John J. Brooks, James E. Wheeler, J E Wheeler, Wheeler JE
Cancer · 1977 · vol. 40(6) , pp. 3065–3073 · doi:10.1002/1097-0142(197712)40:6<3065::aid-cncr2820400645>3.0.co;2-3 · PMID:338141 · W2045717789
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This case report and literature review compiled 45 instances of malignancy in extragonadal endometriosis, primarily adenocarcinomas, with the rectovaginal septum being the most common site.

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Abstract

A case of clear cell carcinoma arising in endometriosis of the retroperitoneum is presented. It occurred 5 years after supracervical hysterectomy and bilateral salpingo-oophorectomy and following 4 years of estrogen therapy. The literature concerning malignancy developing in extragonadal endometriosis has been reviewed and is summarized as follows: 1) 45 cases have been compiled, of which 32 were carcinomas and 13 sarcomas; 2) adenocarcinoma was the most common histologic type, although virtually every tumor of müllerian derivation has been described; 3) the typical patient was nulliparous and perimenopausal; 4) the rectovaginal septum was the most common site, and in general the frequency of malignancy in a given site parallels the frequency of endometriosis in that location; 5) simultaneous tumors of the uterus or ovary were present in seven cases (15%); 6) prognosis appeared affected by site and histologic type; 7) a history of prior pelvic irradiation to effect castration was present in three (9%) of the patients with adenocarcinoma; and 8) four (12%) of the patients with adenocarcinoma were subjected to exogenous estrogens or estrogen-secreting ovarian tumors. Cancer 40:3065-3073, 1977.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Papillary Endometriosis Neoplasms, Multiple Primary Retroperitoneal Neoplasms Adenocarcinoma, Papillary Adult Aged Endometriosis Endometriosis Female Humans Middle Aged Neoplasms, Multiple Primary Neoplasms, Multiple Primary Ovarian Neoplasms Ovarian Neoplasms Parity Pregnancy Prognosis Retroperitoneal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (50)

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