Primary squamous cell carcinoma of the uterine wall associated with adenomyosis: A rare case report and literature review

Li Y, Yang Li, Xuan L, Lanlan Xuan, Q. Wang, Qiucheng Wang, Wang Q
International Journal of Gynecology & Obstetrics · 2025 · vol. 172(1) , pp. 87–91 · doi:10.1002/ijgo.70353 · PMID:40590445 · W4411887619
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This case report describes primary squamous cell carcinoma of the uterine wall in a 49-year-old woman with adenomyosis, misdiagnosed as a leiomyoma before surgical removal and staging.

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Abstract

Primary squamous cell carcinoma (SCC) of the myometrium associated with adenomyosis is exceedingly rare. We present a case involving a 49-year-old female patient who experienced irregular menstruation for 3 months and was initially misdiagnosed with an anterior intramural uterine leiomyoma. The patient underwent a total abdominal hysterectomy with bilateral salpingectomy. Histopathological analysis revealed infiltrative moderately differentiated squamous cell carcinoma. Adenomyosis was also present, with no lesions detected in the cervix, endocervical canal, or uterine cavity. The lesion was localized within the intrinsic muscular layer of the anterior uterine wall. Postoperative diagnosis confirmed stage IIC squamous cell carcinoma of the uterine corpus. A subsequent whole-body positron emission tomography-computed tomography (PET-CT) scan showed no abnormalities. A second surgery at another hospital revealed no abnormalities in the bilateral ovarian, greater omentum, and pelvic lymph nodes.
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Primary squamous cell carcinoma of the uterine wall associated with adenomyosis: A rare case report and literature review Abstract Primary squamous cell carcinoma (SCC) of the myometrium associated with adenomyosis is exceedingly rare. We present a case involving a 49-year-old female patient who experienced irregular menstruation for 3 months and was initially misdiagnosed with an anterior intramural uterine leiomyoma. The patient underwent a total abdominal hysterectomy with bilateral salpingectomy. Histopathological analysis revealed infiltrative moderately differentiated squamous cell carcinoma. Adenomyosis was also present, with no lesions detected in the cervix, endocervical canal, or uterine cavity. The lesion was localized within the intrinsic muscular layer of the anterior uterine wall. Postoperative diagnosis confirmed stage IIC squamous cell carcinoma of the uterine corpus. A subsequent whole-body positron emission tomography-computed tomography (PET-CT) scan showed no abnormalities. A second surgery at another hospital revealed no abnormalities in the bilateral ovarian, greater omentum, and pelvic lymph nodes. CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (16)

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