Endometriosis-related malignancies

G S Leiserowitz, Gary S. Leiserowitz, Gumbs JL, J L Gumbs, Joslyn Gumbs, Richard H. Oi, R Oi, Oi R, John L. Dalrymple, J L Dalrymple, L H Smith, Louisa H. Smith, Smith LH, J Ryu, Ryu J, Jai Min Ryu, S Scudder, Scudder S, Sidney Scudder, A H Russell, Russell AH, Anthony H. Russell
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2003 · vol. 13(4) , pp. 466–471 · doi:10.1046/j.1525-1438.2003.13329.x · PMID:12911723 · W2017453529
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This paper reviews the current understanding of the relationship between endometriosis and various types of malignancies, including ovarian, endometrial, and other cancers.

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Abstract

The purpose of this study is to describe the clinical findings, treatment, and outcome of patients with endometriosis-related cancers. Patients meeting Sampson and Scott's criteria for cancer associated with endometriosis in the Sacramento region were identified by chart review and pathology reports. Twenty-seven patients were identified with endometriosis-related malignancies (mean age 51.4 years). The site of origin was ovary in 17 (63.0%) and extra-ovarian in 10 (37%) including vagina, fallopian tube or mesosalpinx, pelvic sidewall, colon, and parametrium. The pattern of spread was local in five (18.5%), regional in 20 (74.1%) and distant in two (7.4%). Six patients had taken unopposed estrogen replacement (mean duration 23.4 years) and all six had extragonadal disease. Surgical procedures included hysterectomy, salpingo-oophorectomy, radical local excision, partial colectomy, and surgical staging. Eighteen patients received postoperative chemotherapy since the majority of patients had ovarian involvement. Fifteen patients received regional radiation therapy. Nineteen patients are without evidence of recurrence (70.4%, mean follow-up of 31 months). Endometriosis-related malignancies have a favorable prognosis. Extragonadal disease was commonly associated with unopposed estrogen replacement therapy. The predominance of local and regional disease strongly influence the application of treatment modalities.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neoplasms, Multiple Primary Ovarian Neoplasms Pelvic Neoplasms Vaginal Neoplasms Adult Aged Aged, 80 and over Age Distribution Biopsy, Needle California California Cohort Studies Combined Modality Therapy Endometriosis Endometriosis Female Humans Incidence Middle Aged

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Cited by (50)

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License: CC0 · commercial use OK