Malignant transformation of vaginal endometriosis treated with neoadjuvant chemotherapy and surgery

Robert Fruscio, Francesco Padula, Padula F, Mancini E, Emanuela Mancini, Antonio Pellegrino, Michele De Nictolis, De Nictolis M
Journal of Obstetrics and Gynaecology Research · 2008 · vol. 34(4pt2) , pp. 706–708 · doi:10.1111/j.1447-0756.2008.00911.x · PMID:18840186 · W2095732032
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This case report describes a 40-year-old woman with vaginal endometriosis that transformed into endometrioid adenocarcinoma, successfully treated with neoadjuvant chemotherapy and surgery.

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Abstract

Malignant transformation of extragonadal endometriosis is a described. A 40-year-old multiparous woman presented with dyspareunia and dysmenorrhea. Physical examination revealed a 3 x 3.5 cm vaginal nodule. The histological examination of a bioptic sample revealed a moderately differentiated endometrioid adenocarcinoma. The patient was treated with neoadjuvant chemotherapy followed by surgery and is free from disease after 24 months. The frequency of malignant transformation of vaginal endometriosis is unknown. Obesity, hyperestrogenism, and exposure to unopposed estrogen are known risk factors, but were not present in the medical history of the present patient. In our case, preoperative chemotherapy allowed a complete resection without a vaginal demolitive surgery. This therapeutic option may be considered in order to reduce surgical resection and to preserve sexual function. However, because of the rarity of this disease, it is difficult to establish a standard treatment.

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Condition tags

endometriosisdysmenorrheadyspareunia

MeSH descriptors

Adenocarcinoma Endometriosis Vaginal Neoplasms Adenocarcinoma Adenocarcinoma Adenocarcinoma Adenocarcinoma Adult Adult Antineoplastic Agents Antineoplastic Agents Antineoplastic Agents Cell Transformation, Neoplastic Cell Transformation, Neoplastic Chemotherapy, Adjuvant Chemotherapy, Adjuvant Endometriosis Endometriosis Female Female

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (3)

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