Clear cell adenocarcinoma of the vagina in a patient with vaginal endometriosis

Chirag Shah, Pizer E, Ellen Pizer, Ellen S. Pizer, Dan S. Veljovich, Veljovich DS, Charles W. Drescher, Drescher CW, William A. Peters, Peters WA 3rd, Pamela J. Paley, Paley PJ
Gynecologic Oncology · 2006 · vol. 103(3) , pp. 1130–1132 · doi:10.1016/j.ygyno.2006.06.044 · PMID:16996119 · W2048704373
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This case report details clear cell adenocarcinoma of the vagina occurring in a patient with a history of vaginal endometriosis.

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Abstract

BackgroundMalignant transformation of endometriosis is an infrequent complication of endometriosis. Extragonadal disease is uncommon.Case55-year-old female presented with postmenopausal bleeding. Physical examination revealed a 2-cm polypoid lesion at the posterior vaginal apex, which was found to be a moderately differentiated invasive adenocarcinoma. Final pathology at the time of definitive surgery demonstrated a clear cell adenocarcinoma of the vagina arising in vaginal endometriosis.ConclusionVaginal endometriosis may lead to the development of cancer. Malignancy arising in endometriotic foci is rare, but most commonly occurs in the ovary. We report a case of clear cell malignancy arising in vaginal endometriosis, adding to only seven cases previously reported. Risk factors include unopposed estrogen and obesity, but it may occur in the absence of either.

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Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma, Clear Cell Endometriosis Vaginal Neoplasms Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Diagnosis, Differential Endometriosis Endometriosis Endometriosis Endometriosis Female Humans Middle Aged Vaginal Neoplasms Vaginal Neoplasms Vaginal Neoplasms Vaginal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (13)

Cited by (14)

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