Malignant Transformation of Vaginal Endometriosis - A Review of Literature

Mauro Cozzolino, Dimitrios Nasioudis, Giovanni Sisti, Maria Elisabetta Coccia
Gynecologic and obstetric investigation · 2016 · vol. 82(2) , pp. 105–112 · doi:10.1159/000449198 · PMID:27618565 · W2520634453
review OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review of 23 studies and 37 patients found vaginal cancer arising from endometriosis to be rare, most commonly endometrioid adenocarcinoma, with surgery as the main treatment and less favorable outcomes for non-epithelial tumors.

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Abstract

BACKGROUND: The study aimed to examine all available evidence regarding primary vaginal cancer arising from endometriosis from an evidence-based perspective. METHODS: A literature search in Medline and EMBASE databases was conducted. The following key words were employed: 'vaginal cancer' AND 'endometriosis malignant transformation' OR 'endometriosis'. RESULTS: A total of 23 eligible studies were identified and included in the present review providing information for 37 patients. Endometrioid adenocarcinoma (17 cases) was the most common histological subtype followed by endometrial stromal sarcoma (6 cases). The majority of patients received cancer-directed surgery while adjuvant treatment was commonly employed for patients with sarcomas. CONCLUSION: Vaginal cancer arising from endometriosis is exceedingly rare. The mainstay of treatment is surgical excision. Mean follow-up of patients was relative short. Tumor recurrence was often observed, and the outcome was less favorable for patients with non-epithelial tumors.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometriosis Vaginal Neoplasms Cell Transformation, Neoplastic Endometriosis Female Humans Vaginal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

Cited by (11)

Source provenance

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License: CC0 · commercial use OK