Müllerian adenosarcoma of vagina arising in persistent endometriosis: report of a case and review of the literature

Liu L, Lanting Liu, Susan A. Davidson, Susan Davidson, Davidson S, Meenakshi Singh, Singh M
Gynecologic Oncology · 2003 · vol. 90(2) , pp. 486–490 · doi:10.1016/s0090-8258(03)00266-x · PMID:12893226 · W1996330104
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This report details a case of Müllerian adenosarcoma originating in persistent vaginal endometriosis and reviews existing literature on this rare condition.

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Abstract

BackgroundPrimary adenosarcoma arising in vaginal endometriosis poses a diagnostic challenge, especially in superficial vaginal biopsies.CaseA 56-year-old woman, with a prior diagnosis of ovarian endometriosis, presented with a rapidly enlarging mass of the vaginal vault. Two prior biopsies were benign and showed endometriosis. The third vaginal biopsy revealed benign endometriotic glands cuffed by a cellular stroma with moderate cytologic atypia, a histological appearance diagnostic of Müllerian adenosarcoma. A 16-cm vaginal mass that had infiltrated the pelvic structures was resected.ConclusionsClose clinical follow-up of extrauterine endometriosis and clinical-pathologic correlation is necessary. Histological features such as cellular stromal cuffing around benign endometriotic glands are critical in arriving at a timely diagnosis of adenosarcoma in patients with persistent extrauterine endometriosis, even in superficial vaginal biopsies.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Endometriosis Mixed Tumor, Mullerian Vaginal Neoplasms Adenosarcoma Adenosarcoma Endometriosis Endometriosis Female Humans Middle Aged Mixed Tumor, Mullerian Mixed Tumor, Mullerian Vaginal Neoplasms Vaginal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (13)

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