Vaginal Adenosarcoma Arising from Endometriosis

P L Judson, Judson PL, Patricia L. Judson, Ana Maria Temple, A M Temple, Temple AM, Fowler WC Jr, Wesley C. Fowler, W C Fowler, Novotny DB, D B Novotny, Debra B. Novotny, Funkhouser WK Jr, William K. Funkhouser, W K Funkhouser
Gynecologic oncology · 2000 · vol. 76(1) , pp. 123–125 · doi:10.1006/gyno.1999.5617 · PMID:10620454 · W2076616703
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⚙ AI-generated summary by claude@2026-06, 2026-06-11 ⓘ

This paper describes a rare case of vaginal adenosarcoma, a type of uterine cancer, that arose from endometriosis in the vaginal wall.

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Abstract

ObjectiveMalignant transformation of endometriosis has been well documented. Endometrioid adenocarcinoma is the most common malignancy to occur in this setting, although other carcinomas and rarely stromal tumors can be seen. We present the first case in the literature of adenosarcoma, a rare mixed mullerian or mesodermal tumor, arising in extrauterine vaginal endometriosis.CaseA 42-year-old woman underwent multiple medical therapies and surgeries for aggressive endometriosis. A pelvic exenteration was abandoned secondary to severe fibrosis, and low-dose radiotherapy was used to control bleeding from vaginal endometriosis. The pathologic diagnosis of recurrent endometriosis was confirmed multiple times over her 4-year course. Excision of a recurrent vaginal mass revealed adenosarcoma with heterologous elements.ConclusionIt is important to biopsy or excise recurrent endometriosis, as malignant transformation can occur, giving rise to epithelial, stromal, or mixed epithelial-mesenchymal tumors.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Cell Transformation, Neoplastic Endometriosis Vaginal Diseases Vaginal Neoplasms Adenosarcoma Adult Diagnosis, Differential Endometriosis Female Humans Recurrence Vaginal Diseases Vaginal Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (10)

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