Use of Medroxyprogesterone Acetate in the Treatment of Müllerian Adenosarcoma: A Case Report

Hines BJ, Brian J. Hines, Robert F. Porges, Porges RF, Kush Mittal, Mittal K, Franco M. Muggia, John P. Curtin
Gynecologic Oncology · 2002 · vol. 85(1) , pp. 192–195 · doi:10.1006/gyno.2002.6585 · PMID:11925144 · W2121093992
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This case report details the treatment of a patient with Müllerian adenosarcoma using medroxyprogesterone acetate.

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Abstract

BackgroundMüllerianadenosarcoma is a rare pelvic malignancy that most commonly arises from the endometrium. These tumors are relatively insensitive to chemotherapy and radiation and are primarily treated by surgical resection. We report a case of müllerian adenosarcoma arising outside of the uterus from a background of endometriosis treated with a combination of surgical resection and medroxyprogesterone acetate.CaseA 43-year-old woman with a history of endometriosis was diagnosed with advanced extrauterine müllerian adenosarcoma. After suboptimal tumor dubulking surgery she was treated with medroxyprogesterone acetate. Ten months postoperatively she remains without evidence of disease.ConclusionMedroxyprogesterone acetate may be a useful drug in the treatment of advanced müllerian adenosarcoma.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Antineoplastic Agents, Hormonal Genital Neoplasms, Female Medroxyprogesterone Acetate Mixed Tumor, Mullerian Adenosarcoma Adenosarcoma Adult Antineoplastic Agents, Hormonal Combined Modality Therapy Endometriosis Endometriosis Female Genital Neoplasms, Female Genital Neoplasms, Female Humans Medroxyprogesterone Acetate Mixed Tumor, Mullerian Mixed Tumor, Mullerian

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References (9)

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License: CC0 · commercial use OK