Vaginal adenosarcoma arising from endometriosis

P L Judson, Judson PL, Patricia L. Judson, Ana Maria Temple, A M Temple, Temple AM, Fowler WC Jr, Wesley C. Fowler, W C Fowler, Novotny DB, D B Novotny, Debra B. Novotny, Funkhouser WK Jr, William K. Funkhouser, W K Funkhouser
Gynecologic Oncology · 2000 · vol. 76(1) , pp. 123–125 · doi:10.1006/gyno.1999.5617 · PMID:10620454 · W2076616703
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This paper describes a rare case of vaginal adenosarcoma, a type of uterine cancer, that arose from endometriosis in the vaginal wall.

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Abstract

OBJECTIVE: Malignant transformation of endometriosis has been well documented. Endometrioid adenocarcinoma is the most common malignancy to occur in this setting, although other carcinomas and rarely stromal tumors can be seen. We present the first case in the literature of adenosarcoma, a rare mixed mullerian or mesodermal tumor, arising in extrauterine vaginal endometriosis. CASE: A 42-year-old woman underwent multiple medical therapies and surgeries for aggressive endometriosis. A pelvic exenteration was abandoned secondary to severe fibrosis, and low-dose radiotherapy was used to control bleeding from vaginal endometriosis. The pathologic diagnosis of recurrent endometriosis was confirmed multiple times over her 4-year course. Excision of a recurrent vaginal mass revealed adenosarcoma with heterologous elements. CONCLUSION: It is important to biopsy or excise recurrent endometriosis, as malignant transformation can occur, giving rise to epithelial, stromal, or mixed epithelial-mesenchymal tumors.

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Condition tags

endometriosis

MeSH descriptors

Adenosarcoma Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Vaginal Diseases Vaginal Neoplasms Adenosarcoma Adenosarcoma Adult Adult Diagnosis, Differential Diagnosis, Differential Endometriosis Endometriosis Female Female Humans Humans Recurrence Recurrence

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (21)

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