Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis

Hiroshi Kobayashi
International journal of clinical oncology · 2009 · vol. 14(5) , pp. 378–382 · doi:10.1007/s10147-009-0931-2 · PMID:19856043 · W2011247385
review OA: closed CC0 ⤵ 46 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriosis-associated ovarian cancer risk is significantly elevated, with advancing age and larger endometriomas being predictors, and benign masses may precede diagnosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews whether endometriosis-associated ovarian cancer is a distinct clinical entity versus ovarian cancer not associated with endometriosis, using an English-language literature review focused on epidemiology, natural history, and clinical diagnosis. It highlights a prospective Japanese cohort study of 6398 women with ovarian endometrioma followed up to 17 years, in which 46 incident ovarian cancers occurred and risk was significantly elevated (SIR 8.95), with age >40 and endometrioma size >9 cm as independent predictors; it also reports that benign-appearing masses and mildly elevated CA125 often precede diagnosis by years, while serous cancers may progress rapidly de novo. The major limitation is that conclusions are based on a literature review rather than a new systematic comparative analysis within a single study. This paper is centrally about endometriosis — it specifically synthesizes evidence on ovarian cancer risk, development, and diagnosis in the setting of ovarian endometrioma/endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Endometriosis Ovarian Neoplasms Ovarian Neoplasms Precancerous Conditions Precancerous Conditions Adult Age Factors Disease Progression Endometriosis Endometriosis Evidence-Based Medicine Female Humans Japan Japan Mass Screening Mass Screening

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (46)

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