Medical Therapy of Endometriosis
review
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⤵ 63 in-corpus citations
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This review analyzes current and experimental medical treatments for endometriosis, focusing on hormonal therapies and newer molecular targets for managing pain and infertility.
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Abstract
The medical treatment of endometriosis is a critical aspect of the therapeutic approach to this disease. Past methods have been based upon systemic hormonal alterations, resulting in suppression of this estrogen-responsive disorder. Treatments such as danazol, progestogens, oral contraceptives, GnRH-agonists, and gestrinone achieve their effects upon endometriosis via this method. However, with a growing understanding of the pathogenesis of this disease, more precise molecular targets for treatment have been identified. Thus, a series of newer agents are under development and hold the potential of greater efficacy and flexibility than traditional treatments. This review analyzes the available and experimental medical treatments of endometriosis, their utility in the treatment of pain and infertility, and their role in the future.
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Cited by (50)
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- Neuroimmunology of Endometriosis-Associated Pain and Its Psychological Aspects 2024
- The Known, the Unknown and the Future of the Pathophysiology of Endometriosis 2024
- Experience of using drospirenone/ethinyl estradiol combination in women of reproductive age 2024
- Use of the Drospirenone-Only Contraceptive Pill in Adolescents with Endometriosis 2024
- Endometriosis: Cell Death and Cell Signaling Machinery 2023
- COX isozymes and non-uniform neoangiogenesis: What is their role in endometriosis? 2023
- Medical treatments of endometriosis: a review 2022
- Pharmacological Treatment of Chronic Pelvic Pain 2020
- Medical management of endometriosis: what the radiologist needs to know 2020
- New treatment strategy for endometriosis using progestin-primed ovarian stimulation with dienogest: A prospective cohort study, comparison of dienogest versus dydrogesterone 2020
- Endometriosis Pain Management: a Review 2020
- Alterations in β-catenin, microsatellite instability, and HNF-1β levels are independently associated with ovarian endometriosis–associated tumorigenesis 2019
- Endometriosis 2019
- Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions 2019
- Catamenial pneumothorax in a 14-year-old female: A case report and literature review 2019
- Endometriosis 2018
- Disorders of the Peritoneum 2018
- High intensity focused ultrasound treatment of adenomyosis: a comparative study 2018
- Long-term medical management of endometriosis with dienogest and with a gonadotropin-releasing hormone agonist and add-back hormone therapy 2017
- Management of Endometriosis 2015
- Distinct β-Catenin and PIK3CA Mutation Profiles in Endometriosis-Associated Ovarian Endometrioid and Clear Cell Carcinomas 2015
- Current Strategies for Endometriosis Management 2015
- WITHDRAWN: Comparison of endometriotic cysts and ovarian cancer in association with endometriotic cysts 2015
- Predictive factors for the presence of malignant transformation of pelvic endometriosis 2014
- Prevention of Endometriosis 2014
- Treatment of pelvic pain associated with endometriosis: a committee opinion 2014
- Surgically treated ovarian endometriosis association with BRCA1 and BRCA2 mutations 2014
- LC-MS/MS Detection of Increased Androstenedione Levels in Patients Receiving Danazol Therapy 2014
- Clinical use of oral contraceptives 2013
- Clinical Outcome After Radical Excision of Moderate—Severe Endometriosis With or Without Bowel Resection and Reanastomosis 2013
- Endometriosis: An Update on Management 2013
- Sorafenib inhibits growth, migration, and angiogenic potential of ectopic endometrial mesenchymal stem cells derived from patients with endometriosis 2012
- Antiangiogenic agents for endometriosis 2011
- <i>PIK3CA</i> mutation is an early event in the development of endometriosis‐associated ovarian clear cell adenocarcinoma 2011
- The role of prostaglandin E <sub>2</sub> in endometriosis 2011
- Genetic variation in the sex hormone metabolic pathway and endometriosis risk: an evaluation of candidate genes 2011
- Retrospective analysis of follicle loss after laparoscopic excision of endometrioma compared with benign nonendometriotic ovarian cysts 2011
- Deeply Infiltrative Endometriosis: Clinical Outcome after Surgery in Adults and Pathways to Potential Prevention in Adolescents 2011
- Gonadotrophin-releasing hormone analogues for pain associated with endometriosis 2010
- Possible involvement of loss of heterozygosity in malignant transformation of ovarian endometriosis 2010
- Ovarian cancer in endometriosis: epidemiology, natural history, and clinical diagnosis 2009
- Endometriosis causing lower extremity deep vein thrombosis — case report and review of the literature 2009
- Deep pelvic endometriosis: from diagnosis to wellness 2009
- Deep Pelvic Endometriosis: From Diagnosis to Wellness 2009
- Medical treatment of endometriosis. 2009
- Screening, epidemiology, molecular biology, and treatment strategies for endometriosis‐associated ovarian cancer 2009
- Outcome after multidisciplinary CO2 laser laparoscopic excision of deep infiltrating colorectal endometriosis 2009
- Combined laparoscopic surgery and pentoxifylline therapy for treatment of endometriosis-associated infertility: a preliminary trial 2008
- Advances in Treatment Options of Endometriosis 2008
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