Inflammation related to high-mobility group box-1 in endometrial ovarian cyst

Ikeda M, Mariko Ikeda, Yasuyuki Negishi, Akira S, Shigeo Akira, Morita R, Rimpei Morita, Takeshita T, Toshiyuki Takeshita
Journal of Reproductive Immunology · 2021 · vol. 145 , pp. 103292 · doi:10.1016/j.jri.2021.103292 · PMID:33647575 · W3131945849
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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-06-07 ⓘ

This doctoral thesis investigates the relationship between high-mobility group box-1 and inflammation within endometrial ovarian cysts.

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This doctoral thesis investigates inflammation associated with high-mobility group box-1 (HMGB1) in an endometrial ovarian cyst, focusing on HMGB1-linked inflammatory mechanisms within that tissue context. The available record provides only metadata and does not include the thesis’s methods, study population, experimental approach, results, or limitations. Because the full text is not present here, the key findings cannot be determined from the supplied information. This paper is centrally about endometriosis — specifically, it studies inflammation related to HMGB1 in an endometrial ovarian cyst, a key manifestation of endometriosis.

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Abstract

Endometriosis is a chronic inflammatory disease often associated with dysmenorrhea, infertility, adenomyosis, and endometrial ovarian cyst (EOC). In particular, EOC can sometimes become malignant in a longitudinal follow-up. This study aimed to investigate the involvement of high-mobility group box-1 (HMGB1) in an inflammatory milieu and the characteristics of immune cells in EOC. The samples were obtained from patients who underwent ovarian cystectomy for benign ovarian cyst. The participants were divided into two groups: patients with EOC (EOC group) and those without EOC (nEOC group). We divided a part of the removed ovary into small sections and isolated the tissue cells. Thereafter, the cytoplasmic HMGB1 levels in DCs, macrophages, and non-immune cells were analyzed by flow cytometry. We also evaluated the proportions of immune, T, NK, iNKT, NK, and regulatory T (Treg) cells. Results showed that the DCs, macrophages, and non-immune cells of EOC had significantly higher cytoplasmic HMGB1 levels than those of nEOC. The expression of CD69 and CD107a on CD8+ T and CD4+ T cells of EOC was also more enhanced than that of nEOC. Furthermore, the M2 macrophages and Tregs highly accumulated in EOC. These results indicate that HMGB1 may aggravate chronic inflammation related to T-cell activation and simultaneously facilitate development of the immunosuppressive milieu in EOCs.
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WEKO3 アイテム Inflammation related to high-mobility group box-1 in endometrial ovarian cyst https://nms.repo.nii.ac.jp/records/412 https://nms.repo.nii.ac.jp/records/412b193f201-c50a-43ea-acee-8cbb9aa3638c | 名前 / ファイル | ライセンス | アクション | |---|---|---| | 2114_稲津真利子_論文要旨 (373.6 kB) | || | 2114_稲津真利子_審査要旨 (418.3 kB) | | アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | ||||||||||| |---|---|---|---|---|---|---|---|---|---|---|---|---| | 公開日 | 2021-12-08 | ||||||||||| | タイトル | |||||||||||| | タイトル | Inflammation related to high-mobility group box-1 in endometrial ovarian cyst | ||||||||||| | 言語 | en | ||||||||||| | 言語 | |||||||||||| | 言語 | eng | ||||||||||| | キーワード | |||||||||||| | 主題Scheme | Other | ||||||||||| | 主題 | 博士学位論文 | ||||||||||| | 資源タイプ | |||||||||||| | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | ||||||||||| | 資源タイプ | doctoral thesis | ||||||||||| | アクセス権 | |||||||||||| | アクセス権 | metadata only access | ||||||||||| | アクセス権URI | http://purl.org/coar/access_right/c_14cb | ||||||||||| | 著者 | 稲津（池田）, 真利子 × 稲津（池田）, 真利子 | ||||||||||| | 学位名 | |||||||||||| | 学位名 | 博士（医学） | ||||||||||| | 言語 | ja | ||||||||||| | 学位授与機関 | |||||||||||| | 学位授与機関識別子Scheme | kakenhi | ||||||||||| | 学位授与機関識別子 | 32666 | ||||||||||| | 学位授与機関名 | 日本医科大学 | ||||||||||| | 言語 | ja | ||||||||||| | 学位授与年度 | |||||||||||| | 内容記述タイプ | Other | ||||||||||| | 内容記述 | 2021 | ||||||||||| | 学位授与年月日 | |||||||||||| | 学位授与年月日 | 2021-05-19 | ||||||||||| | 学位授与番号 | |||||||||||| | 学位授与番号 | 乙第2114号 | ||||||||||| | 審査日 | |||||||||||| | 日付 | 2021-04-22 |

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Condition tags

endometriosis

MeSH descriptors

Endometriosis HMGB1 Protein Ovarian Cysts Ovary Adult Endometriosis Endometriosis Endometriosis Female HMGB1 Protein Humans Killer Cells, Natural Killer Cells, Natural Killer Cells, Natural Macrophages Macrophages Macrophages Ovarian Cysts Ovarian Cysts Ovarian Cysts

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