Oxidative Stress and Antioxidant Capacity in Patients with Endometrioma

Ichikawa G, Go Ichikawa, Yasuyuki Negishi, Negishi Y, Tsuchiya R, Ryo Tsuchiya, Higuchi L, Lilika Higuchi, Tatsunori Shiraishi, Shiraishi T, Mariko Ikeda, Ikeda M, Kaseki H, Hanako Kaseki, Morita R, Rimpei Morita, Suzuki S, Shunji Suzuki
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2024 · vol. 91(2) , pp. 146–154 · doi:10.1272/jnms.jnms.2024_91-204 · PMID:38432930 · W4392397811
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⚙ AI-generated summary by claude@2026-06, 2026-06-28 ⓘ

Peritoneal fluid from endometrioma patients showed a higher ratio of oxidative stress to antioxidant capacity, correlating with increased CA125 and disease severity scores.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

This study used peritoneal fluid collected at the beginning of surgery from 30 patients with endometrioma (EMO) and 13 patients without EMO (uterine myoma) to assess oxidative stress capacity and antioxidant capacity using d-ROM (reactive oxygen metabolites), BAP (biological antioxidant potential), and their ratio (d-ROM/BAP). The authors found that the d-ROM/BAP ratio was significantly higher in the EMO group than in controls, indicating an imbalance favoring oxidative stress. In patients with EMO, the d-ROM/BAP ratio showed positive correlations with CA125 levels, revised ASRM (r-ASRM) scores, and was used to link oxidative stress status with factors that worsen EMO. This paper is centrally about endometriosis — specifically, it investigates oxidative stress versus antioxidant capacity in peritoneal fluid from patients with endometrioma.

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Abstract

BACKGROUND: Endometriosis has several clinical features, including dysmenorrhea, infertility, and endometrioma (EMO). Although oxidative stress status is closely related to endometriosis, it is unclear how the balance between oxidative stress capacity and antioxidant capacity correlates with treatment of or factors that worsen endometriosis. In this study, we used peritoneal fluid from patients with EMO to investigate the role of oxidative stress capacity and antioxidant capacity. MATERIALS AND METHODS: Participants with EMO (n = 30) and without EMO (uterine myoma, n = 13) were enrolled. All peritoneal fluid samples were collected at the beginning of surgery. We evaluated oxidative stress capacity and antioxidant capacity in peritoneal fluid samples by using the diacron-reactive oxygen metabolites (d-ROM) and biological antioxidant potential (BAP) tests, respectively. The d-ROM and BAP values and the d-ROM/BAP ratio were measured, and their correlations with the CA125 level, revised American Society for Reproductive Medicine (r-ASRM) score, and tumor size were analyzed. RESULTS: The d-ROM/BAP ratio was significantly higher in patients with EMO than in those without EMO. In addition, the d-ROM/BAP ratio was positively correlated with CA125 level and r-ASRM scores in patients with EMO. CONCLUSIONS: Oxidative stress is correlated with factors that worsen EMO. The d-ROM/BAP test may be useful for assessing disease status in patients with EMO.
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Originals Oxidative Stress and Antioxidant Capacity in Patients with Endometrioma 2024 Volume 91 Issue 2 Pages 146-154 Details Abstract Background: Endometriosis has several clinical features, including dysmenorrhea, infertility, and endometrioma (EMO). Although oxidative stress status is closely related to endometriosis, it is unclear how the balance between oxidative stress capacity and antioxidant capacity correlates with treatment of or factors that worsen endometriosis. In this study, we used peritoneal fluid from patients with EMO to investigate the role of oxidative stress capacity and antioxidant capacity. Materials and Methods: Participants with EMO (n = 30) and without EMO (uterine myoma, n = 13) were enrolled. All peritoneal fluid samples were collected at the beginning of surgery. We evaluated oxidative stress capacity and antioxidant capacity in peritoneal fluid samples by using the diacron-reactive oxygen metabolites (d-ROM) and biological antioxidant potential (BAP) tests, respectively. The d-ROM and BAP values and the d-ROM/BAP ratio were measured, and their correlations with the CA125 level, revised American Society for Reproductive Medicine (r-ASRM) score, and tumor size were analyzed. Results: The d-ROM/BAP ratio was significantly higher in patients with EMO than in those without EMO. In addition, the d-ROM/BAP ratio was positively correlated with CA125 level and r-ASRM scores in patients with EMO. Conclusions: Oxidative stress is correlated with factors that worsen EMO. The d-ROM/BAP test may be useful for assessing disease status in patients with EMO. © 2024 by the Medical Association of Nippon Medical School Favorites & Alerts Recently viewed articles Predecessor

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Condition tags

endometriosisendometriomadysmenorrheainfertility

MeSH descriptors

Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants Antioxidants

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