Efficient screening for ovarian cancers using a combination of tumor markers CA602 and CA546

M Saito, Saito M, Masaaki Saito, Aoki D, Daisuke Aoki, D Aoki, N Susumu, Nobuyuki Susumu, Susumu N, Atsushi Suzuki, Suzuki A, A Suzuki, N Suzuki, Nao Suzuki, Suzuki N, Yasuhiro Udagawa, Y Udagawa, Udagawa Y, Nozawa S, Shunsuke Nozawa, S Nozawa
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2005 · vol. 15(1) , pp. 37–44 · doi:10.1111/j.1048-891x.2005.15004.x · PMID:15670295 · W2063136222
article OA: closed CC0 ⤵ 1 in-corpus citation
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper describes a method for efficiently screening ovarian cancers by combining the tumor markers CA602 and CA546.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

A new efficient screening for ovarian cancer based on a combination of two tumor markers, CA602 and CA546, is reported. These two tumor markers can be detected by a combination immunoenzymometric assay of these two antigens. This combination assay was initially performed in 1189 patients with clinically detected ovarian tumors (final pathological diagnosis: 645 cases of benign disease and 544 cases of malignant disease), and benign disease included 122 patients with endometriosis and 523 normal healthy women. The combination of CA602 and CA546 increased the detection rate of ovarian cancer from 77.8 to 85.8% compared with CA602 alone, demonstrating that the combination assay was effective at detecting ovarian cancers. The combination assay of CA602 and CA546 was then applied to 21,374 random subjects to screen for asymptomatic ovarian cancer. Ovarian cancer was detected in nine patients (detection rate: 0.04%), of which four cases were stage I disease. A retrospective analysis of these four patients revealed that a screening based on only a single assay would have been negative and further reiterates the effectiveness of this combination assay in detecting potential disease.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Adenocarcinoma Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Ovarian Neoplasms Adenocarcinoma Adenocarcinoma Adult Antigens, Tumor-Associated, Carbohydrate Biomarkers, Tumor Endometriosis Endometriosis Female Humans Mass Screening Middle Aged Neoplasm Staging Ovarian Neoplasms Ovarian Neoplasms Pilot Projects Retrospective Studies

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (1)

Cited by (1)

References (23)

Cited by (1)

Source provenance

europepmc
last seen: 2026-07-29T06:27:48.050232+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:15:47.114534+00:00
unpaywall
last seen: 2026-07-29T07:08:50.896093+00:00
License: CC0 · commercial use OK