Clinical significance of M2 macrophages expressing heme oxygenase-1 in malignant transformation of ovarian endometrioma

Yuki Yamada, Tomoko Uchiyama, Fuminori Ito, Naoki Kawahara, Kenji Ogawa, Chiho Obayashi, Hiroshi Kobayashi
Pathology, research and practice · 2018 · vol. 215(4) , pp. 639–643 · doi:10.1016/j.prp.2018.12.017 · PMID:30567635 · W2904791625
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study investigated heme oxygenase-1 and macrophage polarization in ovarian endometrioma malignancy, finding HO-1 expression higher in endometrioma cases and a decrease in HO-1-expressing M2 macrophages in cancer cases.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the association between heme oxygenase-1 (HO-1) expression and macrophage polarization during malignant transformation of ovarian endometrioma. Using immunohistochemistry on surgically obtained samples from 53 patients (33 with ovarian endometrioma [OE] and 20 with endometriosis-associated ovarian cancer [EAOC]), the authors assessed macrophage markers CD68, CD11c (M1), CD163 (M2) and HO-1, then performed statistical analyses. HO-1 expression was significantly higher in the OE group than in the EAOC group, and M1 and M2 marker expression (CD11c and CD163) was also significantly higher in OE; specifically, HO-1–expressing M2 macrophages were proportionally reduced in EAOC compared with OE, which the authors relate to changes in the oxidative/antioxidative microenvironment during carcinogenesis, with an explicit limitation of retrospective, observational design. This paper is centrally about endometriosis — it examines HO-1–expressing M2 macrophages in the malignant transformation from ovarian endometrioma to endometriosis-associated ovarian cancer.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cell Transformation, Neoplastic Endometriosis Heme Oxygenase-1 Macrophages Ovarian Diseases Ovarian Neoplasms Adult Aged Biomarkers Biomarkers Cell Transformation, Neoplastic Cell Transformation, Neoplastic Endometriosis Endometriosis Female Heme Oxygenase-1 Humans Macrophages Middle Aged Ovarian Diseases

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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