Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report

Hiroaki Nagano, Yuri Furukawa, Mariko Ueno, Koichiro Takagi
In: Tokyo Women's Medical University Journal, Vol 2, Iss 0, Pp 40-44 (2018) · 2018 · vol. 2 , pp. 40–44 · doi:10.24488/twmuj.2018004 · W2969578195
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This case report describes a 53-year-old woman diagnosed with stage IVB endometrioid carcinoma arising in adenomyosis, presenting with widespread metastases after a four-year follow-up for adenomyosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-12 · read from full text ⓘ

This case report described a patient diagnosed with advanced endometrial cancer that arose in the setting of adenomyosis, focusing on malignant transformation. The authors presented the clinical course and diagnostic context of the endometrial carcinoma developing from adenomyotic tissue, as documented in a single case. As a limitation, the report’s evidence is inherently restricted to one patient and does not establish generalizable risk or mechanisms. This paper is centrally about endometriosis/adenomyosis—specifically, adenomyosis with advanced endometrial cancer arising from malignant transformation.

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Abstract

Endometrial cancer arising in adenomyosis (EC-AIA) is a rare form of uterine cancer. A 53-year-old Japanese postmenopausal female was referred to our outpatient clinic for adenomyosis. After the 4-year follow-up, she presented with an increased vaginal discharge. Endometrial curettage demonstrated either atypical endometrial hyperplasia or well-differentiated endometrioid carcinoma. Positron emission tomography/computed tomography revealed multiple pulmonary metastases, pelvic bone metastases, para-aortic node metastases, and uterine tumor as the primary lesion. She was clinically diagnosed with stage IVB endometrial cancer. Accordingly, total abdominal hysterectomy and bilateral salpingo-oophorectomy were performed. Macroscopic findings of the resected uterus were difficult to distinguish from ordinal adenomyosis. Microscopically, diffuse endometrioid carcinoma (grade 2) occupied the entire uterine body, coexisting with adenomyosis. Postoperatively, chemotherapy and zoledronic acid administration were initiated, which are ongoing till date. The case highlights that EC-AIA, a rare but aggressive disease, should be considered when managing patients with adenomyosis.
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | | 公開日 | 2019-03-15 | | タイトル | | | タイトル | Advanced Endometrial Cancer Arising in Adenomyosis: A Case Report | | 言語 | | | 言語 | eng | | キーワード | | | 主題Scheme | Other | | 主題 | endometrial carcinoma | | キーワード | | | 主題Scheme | Other | | 主題 | adenomyosis | | キーワード | | | 主題Scheme | Other | | 主題 | malignant transformation | | 資源タイプ | | | 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | | 資源タイプ | journal article | | 著者名 | NAGANO, Hiroaki FURUKAWA, Yuri UENO, Mariko TAKAGI, Koichiro | | 出版者 | | | 出版者 | 東京女子医科大学学会 | | 受付日付 | | | 日付 | 2019-03-15 | | 日付タイプ | Created | | ISSN | | | 収録物識別子タイプ | ISSN | | 収録物識別子 | 2432-6186 | | 書誌情報 | Tokyo Women's Medical University Journal 巻 2, p. 40-44, 発行日 2018-12-25 | | DOI | | | 関連タイプ | isIdenticalTo | | | 識別子タイプ | DOI | | | 関連識別子 | https://doi.org/10.24488/twmuj.2018004|10.24488/twmuj.2018004 | | 著者版フラグ | | | 出版タイプ | VoR | | 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | | 著者所属 | | | | Department of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center East | | 著者所属 | | | | Department of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center East | | 著者所属 | | | | Department of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center East | | 著者所属 | | | | Department of Obstetrics and Gynecology, Tokyo Women's Medical University Medical Center East |

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adenomyosis

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