Molecular genetics and epidemiology of epithelial ovarian cancer (Review)

Haruta S, Hiroshi Kobayashi, Shoji Haruta, Naoto Furukawa, Furukawa N, Yoshizawa Y, Yoriko Yoshizawa, Tsunemi T, Taihei Tsunemi, Nagai A, Akira Nagai, Ryuji Kawaguchi, Kawaguchi R, Tanase Y, Yasuhito Tanase, Yoshida S, Shozo Yoshida, Kobayashi H
Oncology reports · 2011 · vol. 26(6) , pp. 1347–56 · doi:10.3892/or.2011.1456 · PMID:21922146 · W2081741157
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Abstract

This review summarizes data from recent molecular genetic and epidemiology studies of the generic term 'female pelvic cancer'. The English-language literature was reviewed for genetic, epigenetic, epidemiologic and environmental risk factors. There are well-documented disparities among racial and ethnic groups with respect to epithelial ovarian cancer (EOC) prevalence. In the case of the serous histological subtype, primary EOC, fallopian tube cancer and peritoneal cancer could be regarded as a single disease entity. However, EOC is not a single disease. Comparing the profile of EOC between Japanese and Caucasians, clear cell carcinomas (27.6%) are more common in Japan, possibly with fewer serous adenocarcinomas (40.7%). This may reflect a proportional increase. The Japanese may exhibit a higher proportion of malignant transformation of endometriosis compared to the United States population. Although some part of the molecular genetic pathogenesis has been unveiled, the complete events of molecular genetic epidemiological changes associated with EOC remain to be identified. This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research.
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Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Review - Authors: - Pages: 1347-1356|Published online on: September 12, 2011https://doi.org/10.3892/or.2011.1456 - Expand metrics + This review summarizes data from recent molecular genetic and epidemiology studies of the generic term ‘female pelvic cancer’. The English-language literature was reviewed for genetic, epigenetic, epidemiologic and environmental risk factors. There are well-documented disparities among racial and ethnic groups with respect to epithelial ovarian cancer (EOC) prevalence. In the case of the serous histological subtype, primary EOC, fallopian tube cancer and peritoneal cancer could be regarded as a single disease entity. However, EOC is not a single disease. Comparing the profile of EOC between Japanese and Caucasians, clear cell carcinomas (27.6%) are more common in Japan, possibly with fewer serous adenocarcinomas (40.7%). This may reflect a proportional increase. The Japanese may exhibit a higher proportion of malignant transformation of endometriosis compared to the United States population. Although some part of the molecular genetic pathogenesis has been unveiled, the complete events of molecular genetic epidemiological changes associated with EOC remain to be identified. This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research. Copy and paste a formatted citation Spandidos Publications style Haruta S, Furukawa N, Yoshizawa Y, Tsunemi T, Nagai A, Kawaguchi R, Tanase Y, Yoshida S and Kobayashi H: Molecular genetics and epidemiology of epithelial ovarian cancer (Review). Oncol Rep 26: 1347-1356, 2011. APA Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R. ... Kobayashi, H. (2011). Molecular genetics and epidemiology of epithelial ovarian cancer (Review). Oncology Reports, 26, 1347-1356. https://doi.org/10.3892/or.2011.1456 MLA Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R., Tanase, Y., Yoshida, S., Kobayashi, H."Molecular genetics and epidemiology of epithelial ovarian cancer (Review)". Oncology Reports 26.6 (2011): 1347-1356. Chicago Haruta, S., Furukawa, N., Yoshizawa, Y., Tsunemi, T., Nagai, A., Kawaguchi, R., Tanase, Y., Yoshida, S., Kobayashi, H."Molecular genetics and epidemiology of epithelial ovarian cancer (Review)". Oncology Reports 26, no. 6 (2011): 1347-1356. https://doi.org/10.3892/or.2011.1456

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Condition tags

endometriosis

MeSH descriptors

Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Ovarian Neoplasms Ovarian Neoplasms Carcinoma, Ovarian Epithelial Diet, High-Fat Diet, High-Fat Endometriosis Endometriosis Female Genes, Neoplasm Hormone Replacement Therapy Hormone Replacement Therapy Humans Incidence Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Ovarian Neoplasms Ovarian Neoplasms Risk Factors

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