Molecular genetics and epidemiology of epithelial ovarian cancer (Review)

Shoji Haruta, Hiroshi Kobayashi, Naoto Furukawa, Yoriko Yoshizawa, Taihei Tsunemi, Akira Nagai, Ryuji Kawaguchi, Yasuhito Tanase, Shozo Yoshida
Oncology reports · 2011 · vol. 26(6) , pp. 1347–56 · doi:10.3892/or.2011.1456 · PMID:21922146 · W2081741157
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Abstract

This review summarizes data from recent molecular genetic and epidemiology studies of the generic term 'female pelvic cancer'. The English-language literature was reviewed for genetic, epigenetic, epidemiologic and environmental risk factors. There are well-documented disparities among racial and ethnic groups with respect to epithelial ovarian cancer (EOC) prevalence. In the case of the serous histological subtype, primary EOC, fallopian tube cancer and peritoneal cancer could be regarded as a single disease entity. However, EOC is not a single disease. Comparing the profile of EOC between Japanese and Caucasians, clear cell carcinomas (27.6%) are more common in Japan, possibly with fewer serous adenocarcinomas (40.7%). This may reflect a proportional increase. The Japanese may exhibit a higher proportion of malignant transformation of endometriosis compared to the United States population. Although some part of the molecular genetic pathogenesis has been unveiled, the complete events of molecular genetic epidemiological changes associated with EOC remain to be identified. This review focuses on current knowledge of the genetic and environmental factors affecting the development of EOC, and outlines future challenges in its pathogenesis research.

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Condition tags

endometriosis

MeSH descriptors

Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Ovarian Neoplasms Ovarian Neoplasms Carcinoma, Ovarian Epithelial Diet, High-Fat Diet, High-Fat Endometriosis Endometriosis Female Genes, Neoplasm Hormone Replacement Therapy Hormone Replacement Therapy Humans Incidence Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial Ovarian Neoplasms Ovarian Neoplasms Risk Factors

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