Malignant Transformation of Endometriosis

Hiroshi Kobayashi
Nihon rinsho. Japanese journal of clinical medicine · 2014 · vol. 70 Suppl 4 , pp. 457–468 · doi:10.1007/978-4-431-54421-0_29 · PMID:23156296 · W213587262
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Endometriosis may undergo malignant transformation into ovarian cancer through atypical endometriosis, with hyperestrogenism, oxidative stress, and iron contributing to carcinogenesis via distinct mechanisms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This paper reviews evidence that women with endometriosis can undergo malignant transformation, outlining a stepwise progression from intermediary endometriotic lesions (atypical endometriosis) to epithelial ovarian cancers, with the highest risk for endometrioid and clear cell histologies. It proposes shared pathogenic mechanisms, emphasizing hyperestrogenism, iron-driven oxidative stress, and inflammation from repeated hemorrhage, and describes three iron-related carcinogenic processes that may support initiation, estrogen-dependent progression, and survival of stressful periods. The chapter’s limitation is that it synthesizes existing epidemiologic and mechanistic findings rather than presenting new experiments, and it concludes that future studies are needed to define exact mechanisms. This paper is centrally about endometriosis — it focuses on the malignant transformation pathway from endometriosis to endometriosis-associated ovarian epithelial cancers.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell Transformation, Neoplastic Endometriosis Ovarian Neoplasms Cell Transformation, Neoplastic Endometriosis Female Humans Ovarian Neoplasms Ovarian Neoplasms

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