Ovarian cancers arising from endometriosis: A microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2

Chiung-Ru Lai, Chiung‐Ru Lai, Chih-Yi Hsu, Chih‐Yi Hsu, Yi‐Jen Chen, Yi-Jen Chen, Ming-Shyen Yen, Kuan-Chong Chao, Anna Fen-Yau Li, Anna Fen–Yau Li
Journal of the Chinese Medical Association : JCMA · 2013 · vol. 76(11) , pp. 629–634 · doi:10.1016/j.jcma.2013.07.008 · PMID:23962610 · W1967975273
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This study investigated the expression of ER, HNF1ß, p53, PTEN, BAF250a, and COX-2 in endometriosis-associated ovarian cancers, finding ER expression linked to endometrioid adenocarcinomas and HNF1ß to clear cell carcinomas.

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Abstract

BACKGROUND: The microenvironmental biomarkers of different subtypes of ovarian cancers arising from endometriosis have not been studied in Taiwan. Their expression can help in understanding the carcinogenic mechanism. METHODS: Our study used immunohistochemistry to compare the expression of estrogen receptor (ER), hepatocyte nuclear factor-1 beta (HNF1ß), p53, phosphatase and tensin homolog (PTEN), BAF250a, and cyclooxygenase-2 (COX-2) among 79 cases of endometriosis-associated ovarian cancers, including 40 (50%) clear cell carcinomas (CCCs), 33 (41%) endometrioid (EM) adenocarcinomas, four (5%) serous carcinomas, one adenosquamous carcinoma, and one adenosarcoma. RESULTS: Positive stainings for ER, HNF1ß, p53, and COX-2 were identified in 34 (43%), 30 (38%), 10 (13%), and 44 (56%) cases. Loss of PTEN and BAF250a were noted in 29 (37%) and 37 (47%) cases. The expression of ER was reversely correlated with that of HNF1ß (rho = -0.417, p < 0.001) and correlated with p53 (rho = 0.284, p = 0.011). ER positivity was commonly identified in EM adenocarcinomas (91%), and rarely in CCCs (8%) and serous carcinoma (0%; p < 0.001). By contrast, HNF1ß expression was frequently noted in CCCs (65%) and serous carcinomas (50%), but less in EM adenocarcinoma (6%; p < 0.001). All staining results were similar between atypical endometriosis glandular epithelium and contiguous malignant parts. Only nine cases showed 10 minor differences (10/474, 2%) in ER, HNF1ß, and BAF250a. For the staining patterns of p53, COX-2, and PTEN, there was no difference between the invasive and precursor parts. CONCLUSION: Our results supported the suggestion that estrogen-dependent ovarian cancer arising from endometriosis is substantially more associated with EM adenocarcinoma than CCCs. The positive HNF1ß staining was a frequent finding in CCCs, but not in EM adenocarcinoma. The similar staining patterns of atypical endometriosis glandular cells with the invasive parts confirmed their precursor status.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Biomarkers, Tumor Endometriosis Ovarian Neoplasms Tumor Microenvironment Adenocarcinoma Adenocarcinoma Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Biomarkers, Tumor Cyclooxygenase 2 Cyclooxygenase 2 DNA-Binding Proteins Endometriosis Endometriosis Female Hepatocyte Nuclear Factor 1-beta Hepatocyte Nuclear Factor 1-beta Humans Neoplasms, Hormone-Dependent Neoplasms, Hormone-Dependent

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