Endometriosis as a risk factor for colorectal cancer

Víctor Manuel Vargas-Hernández, José María Tovar- Rodríguez, Tovar- Rodríguez José María
In: Clinical Journal of Obstetrics and Gynecology · 2020 · vol. 3(2) , pp. 093–097 · doi:10.29328/journal.cjog.1001057 · W3049072897
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review explores endometriosis as a potential risk factor for colorectal cancer, highlighting shared genetic alterations and diagnostic challenges.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This paper is a narrative review examining endometriosis in women of reproductive age and its association with increased malignancy risk, with emphasis that endometriosis cases involving adenomyosis or endometriosis carry the greatest colorectal cancer risk. It synthesizes reported genetic alterations linked to endometriosis–cancer risk and discusses how symptoms, imaging, and endoscopic findings of extragonadal endometriosis can mimic other inflammatory or malignant lesions, complicating preoperative diagnosis; a key limitation is that it compiles existing knowledge rather than presenting new empirical data. The paper’s central message is that endometriosis can be a relevant risk factor in the colorectal cancer context. This paper is centrally about endometriosis — it focuses on endometriosis as a risk factor for colorectal cancer, including extragonadal intestinal involvement.

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Abstract

Endometriosis is a common benign disease in women of reproductive age, it has been associated with an increased risk of various malignancies that is defined by certain histological criteria mainly 80% in ovary and 20% in extragonadal sites such as intestine, rectovaginal septum, abdominal wall, pleura and others; the greatest risk for colorectal cancer is women with adenomyosis or endometriosis; Several genetic alterations have been found in the risk of endometriosis associated with cancer; The symptomatology, imaging and endoscopic characteristics simulate other inflammatory and malignant lesions that make the preoperative diagnosis of extragonadal endometriosis difficult. This is a review of the knowledge about endometriosis and its potential risk of malignancy, particularly with colorectal cancer
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Endometriosis as a risk factor for colorectal cancer Main Article Content Abstract Endometriosis is a common benign disease in women of reproductive age, it has been associated with an increased risk of various malignancies that is defined by certain histological criteria mainly 80% in ovary and 20% in extragonadal sites such as intestine, rectovaginal septum, abdominal wall, pleura and others; the greatest risk for colorectal cancer is women with adenomyosis or endometriosis; Several genetic alterations have been found in the risk of endometriosis associated with cancer; The symptomatology, imaging and endoscopic characteristics simulate other inflammatory and malignant lesions that make the preoperative diagnosis of extragonadal endometriosis difficult. This is a review of the knowledge about endometriosis and its potential risk of malignancy, particularly with colorectal cancer Article Details Copyright (c) 2020 Vargas-Hernández VM, et al. 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