Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery

Sun-Wei Guo; Sun‐Wei Guo

doi:10.1016/j.fertnstert.2015.08.006

Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery

Sun-Wei Guo, Sun‐Wei Guo

Fertility and sterility · 2015 · vol. 104(4) , pp. 813–830 · doi:10.1016/j.fertnstert.2015.08.006 · PMID:26335131 · W1961765983

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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper examines the potential benefits and harms of screening and risk-reducing surgery for individuals with endometriosis in relation to ovarian cancer.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gynecologic Surgical Procedures Gynecologic Surgical Procedures Ovarian Neoplasms Case-Control Studies Cohort Studies Endometriosis Endometriosis Endometriosis Female Humans Mass Screening Mass Screening Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Prevalence Risk Assessment

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References (100)

Cited by (50)

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[1] A clinicopathologic study on the association of endometriosis and carcinoma of the ovary using a scoring system via openalex

[2] Allelotyping of endometriosis with adjacent ovarian carcinoma reveals evidence of a common lineage. via openalex

[3] Analysis of p53 and ras Gene Mutations in Endometriosis via openalex

[4] A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis via openalex

[5] Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis via openalex

[6] A series of ovarian clear cell and endometrioid carcinoma and their association with endometriosis. via openalex

[7] A Series of Ovarian Clear Cell and Endometrioid Carcinoma and their Association with Endometriosis via openalex

[8] Assessing Ovarian Cancer Risk When Considering Elective Oophorectomy at the Time of Hysterectomy via openalex

[9] Association between endometriosis and cancer: A comprehensive review and a critical analysis of clinical and epidemiological evidence via openalex

[10] Atypical epithelial changes and mutant p53 gene expression in ovarian endometriosis via openalex

[11] Benign or Malignant Ovarian Neoplasms and Ovarian Endometriomas via openalex

[12] Bias versus causality: interpreting recent evidence of association between endometriosis and ovarian cancer via openalex

[13] <b>Ovarian atypical endometriosis: its close association with malignant epithelial tumours</b> via openalex

[14] Cancer risk after a hospital discharge diagnosis of endometriosis via openalex

[15] Cancer risk after hospital discharge diagnosis of benign ovarian cysts and endometriosis via openalex

[16] Carcinoma of the Ovary and Endometriosis via openalex

[17] Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer via openalex

[18] Clear cell carcinoma of the ovary: A study of 59 cases via openalex

[19] Clear cell ovarian adenocarcinoma via openalex

[20] c-myc protooncogene polypeptide expression in endometriosis via openalex

[21] Comparative immunohistochemical studies of endometriosis lesions and endometriotic cysts via openalex

[22] Comparative immunohistochemical studies of <i>bcl</i>‐2 and p53 proteins in benign and malignant ovarian endometriotic cysts via openalex

[23] Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress via openalex

[24] Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex

[25] Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK via openalex

[26] Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis via openalex

[27] Endometrial carcinoma of the ovary arising in endometrial tissue in that organ via openalex

[28] ENDOMETRIAL CARCINOMA OF THE OVARY, ARISING IN ENDOMETRIAL TISSUE IN THAT ORGAN via openalex

[29] Endometrioid Adenocarcinoma of the Ovary and Its Relationship to Endometriosis via openalex

[30] Endometrioid and clear cell carcinoma of the ovary via openalex

[31] Endometrioid and Clear Cell Carcinoma of the Ovary via openalex

[32] Endometrioid carcinoma of the ovary via openalex

[33] Endometrioid carcinoma of the ovary. A clinicopathological study of 17 cases. via openalex

[34] Endometrioid carcinoma of the ovary: Retrospective review of 145 cases via openalex

[35] Endometrioid carcinoma of the ovary. Retrospective study. via openalex

[36] Endometriosis via openalex

[37] Endometriosis: A Disease of Oxidative Stress? via openalex

[38] Endometriosis and cancer: what do we know? via openalex

[39] Endometriosis and ovarian cancer via openalex

[40] Endometriosis and Ovarian Cancer: A Systematic Review via openalex

[41] Endometriosis and the risk of cancer with special emphasis on ovarian cancer via openalex

[42] Endometriosis as a prognostic factor for cancer survival via openalex

[43] Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis via openalex

[44] Endometriosis-Associated Ovarian Carcinoma (EAOC): An Entity Distinct from Other Ovarian Carcinomas as Suggested by a Nested Case-Control Study via openalex

[45] Endometriosis: Current Management and Future Trends via openalex

[46] Endometriosis Does Not Confer Improved Prognosis in Ovarian Carcinoma of Uniform Cell Type via openalex

[47] Endometriosis: epidemiology and aetiological factors via openalex

[48] Endometriosis in Rhesus Monkeys (Macaca mulatta) Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin via openalex

[49] Endometriosis: pathogenesis and treatment via openalex

[50] Endometriosis: Pathogenesis, diagnosis, therapy and association with cancer (Review) via openalex

[51] EPIDEMIOLOGY OF ENDOMETRIOSIS via openalex

[52] Estrogen Production and Metabolism in Endometriosis via openalex

[53] Evidence for a Hypercoagulable State in Women With Ovarian Endometriomas via openalex

[54] Evidence for Oxidatively Modified Lipid-Protein Complexes in Endometrium and Endometriosis via openalex

[55] Frequency of ovarian endometriosis in epithelial ovarian cancer patients. via openalex

[56] Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis via openalex

[57] Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: A high degree of differentiation rather than malignant potential via openalex

[58] Genomic Alterations in Ectopic and Eutopic Endometria of Women with Endometriosis via openalex

[59] Heritable aspects of endometriosis via openalex

[60] Histologic Transformation of Benign Endometriosis to Early Epithelial Ovarian Cancer via openalex

[61] Hormonal and surgical treatments for endometriosis and risk of epithelial ovarian cancer via openalex

[62] Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells via openalex

[63] Identification of an Invasive, N-Cadherin-Expressing Epithelial Cell Type in Endometriosis Using a New Cell Culture Model via openalex

[64] Immunolocalization of the apoptosis regulating proteins Bcl-2 and Bax in human endometrium and isolated peritoneal fluid macrophages in endometriosis via openalex

[65] Increased risk for ovarian cancer and borderline ovarian tumours in subfertile women with endometriosis via openalex

[66] In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk via openalex

[67] Involvement of the nuclear factor-κB pathway in the pathogenesis of endometriosis via openalex

[68] Involvement of the Wnt/β-Catenin Signaling Pathway in the Cellular and Molecular Mechanisms of Fibrosis in Endometriosis via openalex

[69] Is early age at menarche a risk factor for endometriosis? A systematic review and meta-analysis of case-control studies via openalex

[70] K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma via openalex

[71] Lipocalin 2 induces the epithelial–mesenchymal transition in stressed endometrial epithelial cells: possible correlation with endometriosis development in a mouse model via openalex

[72] Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. via openalex

[73] Malignant changes in endometriosis. via openalex

[74] Markers of inflammation and risk of ovarian cancer in Los Angeles County via openalex

[75] Mesonephroid carcinoma of the ovary: A study of 95 cases from the Emil Novak Ovarian Tumor Registry via openalex

[76] “Mesonephroma” of ovary. Tumor of müllerian nature related to the endometrioid carcinoma via openalex

[77] Mesonephroma of the ovary.A clinical, morphological, and histogenetic appraisal via openalex

[78] Microsatellite analysis of endometriosis reveals loss of heterozygosity at candidate ovarian tumor suppressor gene loci. via openalex

[79] Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis via openalex

[80] Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review). via openalex

[81] New insights in the pathophysiology of ovarian cancer and implications for screening and prevention via openalex

[82] No evidence of endometriosis within serous and mucinous tumors of the ovary. via openalex

[83] Novel insights on the malignant transformation of endometriosis into ovarian carcinoma via openalex

[84] Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? via openalex

[85] Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis via openalex

[86] Oral contraceptives and risk of endometriosis: a systematic review and meta-analysis via openalex

[87] Ovarian adenocarcinoma of mesonephric type via openalex

[88] Ovarian cancer risk associated with varying causes of infertility via openalex

[89] Ovarian cancers arising from endometriosis: A microenvironmental biomarker study including ER, HNF1ß, p53, PTEN, BAF250a, and COX-2 via openalex

[90] Ovarian carcinoma associated with endometriosis via openalex

[91] Ovarian Endometriosis Associated with Ovarian Carcinoma: A Clinicopathological and Immunohistochemical Study via openalex

[92] Oxidative stress and endometriosis via openalex

[93] Oxidative stress and peritoneal endometriosis via openalex

[94] Oxidative stress status in normal ovarian cortex surrounding ovarian endometriosis via openalex

[95] p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer via openalex

[96] Peritoneal endometriosis due to the menstrual dissemination of endometrial tissue into the peritoneal cavity via openalex

[97] Peritoneal endometriosis is an inflammatory disease via openalex

[98] Peritoneal endometriosis is an inflammatory disease via openalex

[99] Platelets are an unindicted culprit in the development of endometriosis: clinical and experimental evidence via openalex

[100] Population Distribution of Lifetime Risk of Ovarian Cancer in the United States via openalex