Evidence for Oxidatively Modified Lipid-Protein Complexes in Endometrium and Endometriosis
article
OA: closed
CC0
⤵ 60 in-corpus citations
AI-generated summary
Researchers identified oxidatively modified lipid-protein complexes in human endometrium and endometriosis tissue samples.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
ObjectiveTo evaluate for the presence of oxidatively modified lipid-protein complexes in endometriosis and endometrium of women with endometriosis and controls.DesignControlled clinical study.SettingAcademic tertiary care center.Patient(s)Women undergoing surgery for pelvic pain, infertility, endometriosis, or tubal ligation controls.Intervention(s)Biopsy of endometrium and endometriosis.Main outcome measure(s)Staining with antibodies to oxidatively modified lipid proteins (HNE-7, MDA2), macrophages (HAM-56), and muscle cell actin (HHF-35).Result(s)Both endometrium and endometriosis tissues contain stromal cells that immunostain with HAM-56 and show immunostaining (both intracellular and extracellular) with HNE-7 and MDA2. Some endometriotic implants show patchy staining with HHF-35. Endometrium was devoid of staining with HHF-35. Control staining with nonimmune sera in both tissues was also devoid of staining.Conclusion(s)These data strongly implicate the occurrence of oxidative stress in endometriosis tissue. These data also suggest that oxidative modification is a normal physiological process in endometrium.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (5)
- W152815097 via openalex
- W1857052429 via openalex
- W1968679020 via openalex
- W1991726504 via openalex
- W6606146908 via openalex
Cited by (50)
- Ramipril ameliorates endometriosis by inducing oxidative stress-mediated apoptosis in the wistar rat 2025
- Diagnostic Value of Menstrual Blood Lipidomics in Endometriosis: A Pilot Study 2024
- Copper homeostasis and cuproptosis in gynecological disorders: Pathogenic insights and therapeutic implications 2024
- The cGAS-STING pathway promotes endometriosis by up-regulating autophagy 2023
- Exosomal microRNAs and long noncoding RNAs: as novel biomarkers for endometriosis 2023
- Metabolomics in endometriosis: challenges and perspectives for future studies 2021
- Endometriosis Pain Management: a Review 2020
- The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression 2019
- Current assessment of the (dys)function of macrophages in endometriosis and its associated pain 2019
- The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner 2018
- Pengaruh Pemberian Ekstrak Meniran Terhadap Ekspresi MMP 9 Dan Luas Lesi Endometriosis Pada Mencit Model Endometriosis 2018
- Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women 2017
- Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis 2017
- Oxidative Stress Statues in Serum and Follicular Fluid of Women with Endometriosis. 2017
- Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics 2016
- Effects of aloe vera gel on the induction of endometriosis and regression of endometrial explants in a rat model 2016
- The effects of thalidomide in a rat model of surgically-induced endometriosis 2015
- Novel Medical Treatment Modalities of Endometriosis 2015
- Endometriosis and ovarian cancer: potential benefits and harms of screening and risk-reducing surgery 2015
- Theories on the Pathogenesis of Endometriosis 2014
- Oxidative stress in breast and gynaecological carcinogenesis 2014
- Mitochondrial DNA 4977-bp deletion in endometriosis 2013
- Mitochondrial displacement loop alterations are associated with endometriosis 2013
- Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first-generation and second-generation embryos 2013
- Effects of amifostine on endometriosis, comparison with N-acetyl cysteine, and leuprolide as a new treatment alternative: a randomized controlled trial 2013
- The role of iron metabolism and oxidative stress in the pathogenesis of endometriosis 2013
- Increased levels of oxidative stress markers in the peritoneal fluid of women with endometriosis 2013
- Asociación entre endometriosis pélvica y estrés oxidativo 2013
- Low-Density Lipoproteins Oxidation and Endometriosis 2013
- Endometriosis and Oxidative Stress 2012
- Analysis of follicular fluid and serum markers of oxidative stress in women with infertility related to endometriosis 2012
- Antioxidant supplementation reduces endometriosis-related pelvic pain in humans 2012
- Down-regulation of 8-hydroxydeoxyguanosine and peroxiredoxin II in the pathogenesis of endometriosis-associated ovarian cancer. 2012
- Cellular and molecular basis for endometriosis-associated infertility 2012
- Pathogenesis of endometriosis: the role of genetics, inflammation and oxidative stress 2012
- Green Tea for Endometriosis 2012
- New trends for the medical treatment of endometriosis 2012
- Mitochondrial Genome Variations in Advanced Stage Endometriosis: A Study in South Indian Population 2012
- Lien hypothétique entre l’endométriose et l’accumulation de xénobiotiques associés aux aliments génétiquement modifiés 2010
- Leptin and Antioxidant Profile in Infertile Women with Endometriosis 2010
- Leptin and antioxidant profile in infertile women with endometriosis 2010
- Female Infertility and Antioxidants 2010
- Atorvastatin causes regression of endometriotic implants in a rat model 2009
- The role of the oxidative-stress in the endometriosis-related infertility 2009
- Lipid peroxidation and vitamin E in serum and follicular fluid of infertile women with peritoneal endometriosis submitted to controlled ovarian hyperstimulation: a pilot study 2008
- Role of melatonin in regulating matrix metalloproteinase‐9 via tissue inhibitors of metalloproteinase‐1 during protection against endometriosis 2008
- Regression of endometrial explants in a rat model of endometriosis treated with melatonin 2007
- Comparative proteomic analysis of human adenomyosis using two-dimensional gel electrophoresis and mass spectrometry 2007
- Peroxidação lipídica e vitamina E no soro e no fluido folicular de mulheres inférteis com endometriose submetidas à estimulação ovariana controlada 2007
- Role of oxidative stress in endometriosis 2006
Source provenance
- europepmc
- last seen: 2026-09-27T09:11:36.575535+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:10:40.754221+00:00
- unpaywall
- last seen: 2026-09-17T06:32:46.214484+00:00
License: CC0
· commercial use OK