Lien hypothétique entre l’endométriose et l’accumulation de xénobiotiques associés aux aliments génétiquement modifiés

Aris A, Kenneth Paris, A. Aris, K Paris, Paris K
Gynecologie, obstetrique & fertilite · 2010 · vol. 38(12) , pp. 747–753 · doi:10.1016/j.gyobfe.2010.08.030 · PMID:21111655 · W2136502020
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This hypothetical study explores a potential link between endometriosis and the accumulation of xenobiotics found in genetically modified foods.

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Abstract

Endometriosis is an oestrogen-dependent inflammatory disease affecting 10 % of reproductive-aged women. Often accompanied by chronic pelvic pain and infertility, endometriosis rigorously interferes with women's quality of life. Although the pathophysiology of endometriosis remains unclear, a growing body of evidence points to the implication of environmental toxicants. Over the last decade, an increase in the incidence of endometriosis has been reported and coincides with the introduction of genetically modified foods in our diet. Even though assessments of genetically modified food risk have not indicated any hazard on human health, xenobiotics-associated genetically modified food, such as pesticides residues and xenoproteins, could be harmful in the long-term. The "low-dose hypothesis", accumulation and biotransformation of pesticides-associated genetically modified food and the multiplied toxicity of pesticides-formulation adjuvants support this hypothesis. This review summarizes toxic effects (in vitro and on animal models) of some xenobiotics-associated genetically modified food, such as glyphosate and Cry1Ab protein, and extrapolates on their potential role in the pathophysiology of endometriosis. Their roles as immune toxicants, pro-oxidants, endocrine disruptors and epigenetic modulators are discussed.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Food, Genetically Modified Xenobiotics Animals Bacillus thuringiensis Toxins Bacterial Proteins Bacterial Proteins DNA Damage Endocrine Disruptors Endocrine Disruptors Endometriosis Endotoxins Endotoxins Epigenomics Female Food, Genetically Modified Hemolysin Proteins Hemolysin Proteins Humans Infertility, Female

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License: CC0 · commercial use OK