Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis

Ota H, Hirotaka Ota, H. Ota, Shinichi Igarashi, Igarashi S, S. Igarashi, Tanaka T, Toshinobu Tanaka, T Tanaka
Fertility and sterility · 2001 · vol. 75(4) , pp. 785–790 · doi:10.1016/s0015-0282(01)01670-3 · PMID:11287035 · W1978165903
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This study investigated the presence and activity of xanthine oxidase in eutopic and ectopic endometrial tissues from patients with endometriosis and adenomyosis.

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Abstract

ObjectiveTo investigate the expression of xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis.DesignImmunohistochemical identification of xanthine oxidase in endometrial tissues by using polyclonal antibody.SettingUniversity hospital.Patient(s)Thirty-four women with endometriosis, 34 women with adenomyosis, and 44 fertile control women.Intervention(s)Biopsy samples were obtained from the endometrium throughout the menstrual cycle.Main outcome measure(s)Semiquantitative immunostaining (evaluation nomogram) score of endometrial cells.Result(s)The level of xanthine oxidase expression in the glandular epithelium of control varied according to menstrual phase, but no such variation in expression was seen in endometriosis. Variation in xanthine oxidase expression was observed during the menstrual cycle in patients with adenomyosis; this variation differed completely from that in controls. Xanthine oxidase expression was found in ectopic endometrial tissue in all cases. The mean evaluation nomogram levels in the glandular epithelium in adenomyosis tissue were as high as those in the early secretory phase in the eutopic endometrium.Conclusion(s)Aberrant expression of xanthine oxidase in eutopic and ectopic endometrium appears to play a pathologic role in endometriosis and adenomyosis.

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

Choristoma Endometriosis Endometrium Endometrium Xanthine Oxidase Anemia, Iron-Deficiency Anemia, Iron-Deficiency Choristoma Choristoma Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometrium Female Fertility Humans Hysterectomy Immunohistochemistry

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (31)

Cited by (46)

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License: CC0 · commercial use OK