CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY

L.Yu. Karakhalis, A. R. Jhigalenko, G. A. Penjhoyan, Н. В. Колесникова
In: Kubanskij nauchnyj medicinskij vestnik · 2017 · pp. 37–44 · doi:10.25207/1608-6228-2017-24-5-37-44 · W2772090279
article OA: diamond CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study assessed changes in L-selectin, neopterin, and interleukin-6 in adenomyosis patients with infertility and found L-selectin useful for monitoring therapy effectiveness, with gestagens showing better normalization.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This paper studied 49 infertile women with adenomyosis to determine how adhesion molecules (L-selectin, neopterin, and interleukin-6) change over the course of therapy, using ELISA and assessing adenomyosis symptoms by a VAS scale. The authors formed three groups (two adenomyosis-associated infertility groups and a control group) and found that L-selectin showed statistically significant pre- vs post-treatment differences with a reported correlation coefficient (R=0.584), which they describe as having diagnostic significance for monitoring treatment effectiveness. They report that gestagens were associated with normalization of L-selectin and reduced VAS intensity of dysmenorrhea and dyspareunia compared with another group, while adenomyosis was not accompanied by a substantial increase in neopterin or IL-6 production; the caveat is that the paper focuses on these circulating markers rather than direct tissue or mechanistic measures. Relevance to endometriosis: adenomyosis is explicitly framed within the paper’s immunologic context (with citations about endometriosis and adenomyosis immune-related markers), though the study’s main focus is adenomyois-associated infertility treatment monitoring via adhesion molecules.

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Abstract

Aim . The aim of this study was to asses changes of adhesion molecules (L-selectin, neopterin and interleukin-6) in patients with adenomyosis-related infertility during the therapy. Materials and methods. 49 patients with infertility caused by adenomyosis were examined and divided into 3 clinical groups: 1 group – 26 patients (35,1%) and 2 group – 23 patients (31,1%) with adenomyosis-associated infertility; 3 group (control) – 25 patients (33,8%). Adhesion molecules detection was performed by enzyme immunoassay (EIA). Visual evaluation scale was used for estimating of clinical aspects of adenomyosis. Results. The diagnostic utility of L-selectin for monitoring the adenomyosis therapy effectiveness was shown. The difference between L-selectin levels before and after treatment was statistically significant, the correlation coefficient (R) reached 0,584. The gestagens application is preferable due to reliable normalization of L-selectin levels and decrease in intensity of algomenorrhea (in the 1st group – 1,3 times less, than in 2nd group) and dyspareunia (in the 1st group – 2,2 times less, than in the 2nd group) on visual evaluation scale. Conclusions. Adenomyosis not accompanied by a significant increase in the production of systematic inflammatory response markers (neopterin and IL-6), the increase of adhesion molecules (L-selectin) indicates the imbalance of endothelial-thrombocyte-leukocyte interaction.

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adenomyosisdyspareuniainfertility

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