The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients

Nura Fitnat Topbaş Selçuki, Pınar Yalçın Bahat, Cihan Kaya, Salim Neşeli̇oğlu, Kubra Bagci Cakmak, Kubra BAGCI, Mustafa Göksu, Meric Kabakcı, Özcan Erel
In: Marmara Medical Journal · 2022 · doi:10.5472/marumj.1120611 · W4281928812
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This study found no significant difference in dynamic thiol/disulfide homeostasis or ischemia modified albumin levels between endometriosis patients and controls, limiting the use of these markers for systemic oxidative stress in endometriosis.

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This prospective case-control study evaluated oxidative stress in 86 endometriosis patients with persistent endometriomas by measuring dynamic thiol/disulfide homeostasis and ischemia-modified albumin (IMA) levels in serum, compared with 60 control patients undergoing routine gynecologic care. The thiol/disulfide parameters showed no significant differences between groups, with both disulfide levels and overall thiol/disulfide homeostasis statistically similar, and there were also no group differences in IMA and albumin levels. The authors conclude that dynamic thiol/disulfide homeostasis was not significantly altered systemically in endometriosis and note that, despite being a proposed oxidative stress marker in other chronic inflammatory diseases, its utility for reflecting systemic oxidative stress in endometriosis is limited. This paper is centrally about endometriosis — it tests whether dynamic thiol/disulfide homeostasis and IMA differ between endometriosis patients and controls to evaluate oxidative stress.

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Abstract

Objective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels. Patients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group. Thiol/disulfide parameters and IMA levels were determined from the serum samples. Results: When the thiol/disulfide parameters were compared between the study and the control group no significant difference was observed (p=0.49). Mean disulfide level in the control group was 18.58 ± 5.73 μmol/L and in the study group was 18.61 ± 7.37 μmol/L. Levels were statistically similar in both groups (p=0.98). In addition, there were no differences between the groups in terms of IMA and albumin levels. Conclusion: The results of this study revealed no significant difference in the dynamic thiol/disulfide homeostasis among the endometriosis patients. Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.
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Abstract

Objective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels. Patients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group. Thiol/disulfide parameters and IMA levels were determined from the serum samples.

Results

When the thiol/disulfide parameters were compared between the study and the control group no significant difference was observed (p=0.49). Mean disulfide level in the control group was 18.58 ± 5.73 μmol/L and in the study group was 18.61 ± 7.37 μmol/L. Levels were statistically similar in both groups (p=0.98). In addition, there were no differences between the groups in terms of IMA and albumin levels.

Conclusion

The results of this study revealed no significant difference in the dynamic thiol/disulfide homeostasis among the endometriosis patients. Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.

Keywords

References - [1] Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med 2020; ;382:1244-56. doi: 10.1056/NEJMra1810764 - [2] Sampson JA. Perforating hemorrhagic (chocolate) cysts of the ovary: Their importance and especially their relation to pelvic adenomas of endometrial type (Adenomyoma of the uterus, rectovaginal septum, sigmoid, etc.). Arch Surg 1921;3:245- 323. doi:10.1001/archsurg.1921.011.10080003001 - [3] Sampson JA. Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 1927;3:93-110.43. PMID: 19969738 - [4] Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol 2001;96:21- 34. doi: 10.1016/s0301-2115(00)00405-x - [5] Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertil Steril 2004;82 Suppl 3:1019-22. doi: 10.1016/j.fertnstert.2004.02.133 - [6] Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, Creatsas G. The role of the oxidative-stress in the endometriosis-related infertility. Gynecol Endocrinol 2009;25:75-81. doi: 10.1080/095.135.90802485012 - [7] Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G. Pathogenesis of endometriosis: The role of defective ‘immunosurveillance.’ Eur J Contracept Reprod Health Care 2007;12:194-202. doi: 10.1080/136.251.80701387266 - [8] Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol RBE. 2005 Jul;3:28. doi: 10.1186/1477-7827-3-28 Details Primary Language English Subjects Clinical Sciences Journal Section Research Article Authors Nura Fitnat Topbas Selcukı * This is me 0000-0002-5749-9987 Türkiye Pinar Yalcın Bahat This is me Türkiye Cihan Kaya This is me Türkiye Salim Neselıoglu This is me 0000-0002-0974-5717 Türkiye Kubra Bagcı This is me 0000-0001-6435-0059 Türkiye Mustafa Goksu This is me 0000-0002-6389-9178 Türkiye Meric Kabakcı This is me 0000-0002-6956-6753 Türkiye Ozcan Erel This is me 0000-0002-2996-3236 Türkiye Publication Date May 30, 2022 Submission Date November 20, 2021 Acceptance Date - Published in Issue Year 2022 Volume: 35 Number: 2

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