{"paper_id":"bb413315-d748-4275-9c5a-781905d3bd6d","body_text":"The role of dynamic thiol/disulfide homeostasis for the evaluation of oxidative stress in endometriosis patients\nAbstract\nObjective: To evaluate the role of oxidative stress in endometriosis patients by determining dynamic thiol/disulfide homeostasis and ischemia modified albumin (IMA) levels.\nPatients and Methods: This prospective case-controlled study was conducted at a tertiary gynecology clinic in Istanbul, Turkey. 86 patients previously diagnosed with endometriosis and persistent endometriomas were included in the study group. 60 patients who visited the clinic during the study period for routine gynecological control were included in the control group. Thiol/disulfide parameters and IMA levels were determined from the serum samples.\nResults: When the thiol/disulfide parameters were compared between the study and the control group no significant difference was observed (p=0.49). Mean disulfide level in the control group was 18.58 ± 5.73 μmol/L and in the study group was 18.61 ± 7.37 μmol/L. Levels were statistically similar in both groups (p=0.98). In addition, there were no differences between the groups in terms of IMA and albumin levels.\nConclusion: The results of this study revealed no significant difference in the dynamic thiol/disulfide homeostasis among the endometriosis patients. Although, it has been accepted as a potential oxidative stress marker in other chronic inflammatory diseases, its use in determining the systemic oxidative stress level in endometriosis patients is limited.\nKeywords\nReferences\n- [1] Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med 2020; ;382:1244-56. doi: 10.1056/NEJMra1810764\n- [2] Sampson JA. Perforating hemorrhagic (chocolate) cysts of the ovary: Their importance and especially their relation to pelvic adenomas of endometrial type (Adenomyoma of the uterus, rectovaginal septum, sigmoid, etc.). Arch Surg 1921;3:245- 323. doi:10.1001/archsurg.1921.011.10080003001\n- [3] Sampson JA. Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation. Am J Pathol 1927;3:93-110.43. PMID: 19969738\n- [4] Vinatier D, Orazi G, Cosson M, Dufour P. Theories of endometriosis. Eur J Obstet Gynecol Reprod Biol 2001;96:21- 34. doi: 10.1016/s0301-2115(00)00405-x\n- [5] Foyouzi N, Berkkanoglu M, Arici A, Kwintkiewicz J, Izquierdo D, Duleba AJ. Effects of oxidants and antioxidants on proliferation of endometrial stromal cells. Fertil Steril 2004;82 Suppl 3:1019-22. doi: 10.1016/j.fertnstert.2004.02.133\n- [6] Augoulea A, Mastorakos G, Lambrinoudaki I, Christodoulakos G, Creatsas G. The role of the oxidative-stress in the endometriosis-related infertility. Gynecol Endocrinol 2009;25:75-81. doi: 10.1080/095.135.90802485012\n- [7] Christodoulakos G, Augoulea A, Lambrinoudaki I, Sioulas V, Creatsas G. Pathogenesis of endometriosis: The role of defective ‘immunosurveillance.’ Eur J Contracept Reprod Health Care 2007;12:194-202. doi: 10.1080/136.251.80701387266\n- [8] Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol RBE. 2005 Jul;3:28. doi: 10.1186/1477-7827-3-28\nDetails\nPrimary Language\nEnglish\nSubjects\nClinical Sciences\nJournal Section\nResearch Article\nAuthors\nNura Fitnat Topbas Selcukı\n*\nThis is me\n0000-0002-5749-9987\nTürkiye\nPinar Yalcın Bahat\nThis is me\nTürkiye\nCihan Kaya\nThis is me\nTürkiye\nSalim Neselıoglu\nThis is me\n0000-0002-0974-5717\nTürkiye\nKubra Bagcı\nThis is me\n0000-0001-6435-0059\nTürkiye\nMustafa Goksu\nThis is me\n0000-0002-6389-9178\nTürkiye\nMeric Kabakcı\nThis is me\n0000-0002-6956-6753\nTürkiye\nOzcan Erel\nThis is me\n0000-0002-2996-3236\nTürkiye\nPublication Date\nMay 30, 2022\nSubmission Date\nNovember 20, 2021\nAcceptance Date\n-\nPublished in Issue\nYear 2022 Volume: 35 Number: 2","source_license":"CC0","license_restricted":false}