Endometriosis and Free Radicals

Hirotaka Ota, H Ota, Shinichi Igarashi, S Igarashi, J Hatazawa, T Tanaka, Toshinobu Tanaka
Gynecologic and obstetric investigation · 1999 · vol. 48(Suppl. 1) , pp. 29–35 · doi:10.1159/000052866 · PMID:10559662 · W2066985479
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Endometriosis exhibits overexpression of nitric oxide synthase and superoxide dismutase throughout the menstrual cycle, suggesting excessive free radical production in the disease.

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Abstract

Recent studies have shown that synthase for nitric oxide or scavenger enzymes is distributed throughout the endometrium. We have reported that endothelial nitric oxide synthase, originally identified in vascular endothelial cells, is distributed in glandular epithelial cells in the endometrium, peaking in the midsecretory phase. In addition, it is known that superoxide dismutase is distributed throughout the endometrium, varying with the menstrual cycle. Yet it is not clear how these enzymes are committed in the reproductive processes. Endometriosis is often complicated by infertility and miscarriage. Of particular interest is that these enzymes are overexpressed in the disease throughout the menstrual cycle. These findings strongly suggest that excessive amounts of free radicals are produced in endometriosis. Copyrightz1999S.KargerAG,Basel

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Gene Expression Regulation, Enzymologic Infertility, Female Nitric Oxide Nitric Oxide Synthase Adult Endometriosis Endometriosis Female Free Radicals Free Radicals Humans Infertility, Female Menstrual Cycle Menstrual Cycle Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Superoxides Superoxides

Citation neighborhood

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References (52)

Cited by (32)

Source provenance

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