The Correlation Between the Degree of Pain with Estradiol Hormone Levels, Interleukin 1β (il-1β) Levels and Nitrite Oxide in Blood Serum of Endometriosis Patients

Endometriosis is the chronic disease, in which the glandular and stromal-like endometrium grows outside the uterine cavity, Endometriosis is inflammatory and estrogen-dependent that affects 6-10% of women during their reproductive years and up to 50% of women receiving fertility treatment. The purpose of this study was to determine the correlation between the degree of pain with estradiol hormone levels, interleukin-1β (IL-1β) levels and Nitrite Oxide (NO) in the blood serum of patients with endometriosis. This type of research is an observational analytic with a cross sectional comparative study design in which the dependent and independent variables are obtained simultaneously. The research was conducted in type B and C hospitals. To take blood serum samples for endometriosis patients and the Biomedical Laboratory of FK Unand to check levels of estradiol hormone, levels of Interleukin-1β (IL-1β) and NO. The study was conducted in January - November 2020. The population was all patients who doing examination at the obstetrics gynecology department of the hospital. Samples were taken consecutively that met the inclusion and exclusion criteria with a total sample of 40 people. Data analysis using analyzed by univariate, bivariate and multivariate with chi-square test. The research results were obtained The mean age of endometriosis patients was 38.85 years, the mean pain degree of patients and the distribution of levels of estradiol, interleukin, 1β (IL-1β) and Nitric oxide. The results of the bivariate analysis showed that there were differences degree of pain with each Estradiol level, interleukin, 1β (IL-1β) as well as nitric oxide. The results of the multivariate analysis showed that there was a difference in the degree of pain with the three Estradiol levels. interleukin, 1β (IL-1β) and nitric oxide in the blood serum of people with endometriosis (P = 0,000 then p [α (0.05). From the research results it can be concluded that there are the relationship between degree of pain and level Estradiol, interleukin, 1β (IL-1β) and nitric oxide in the blood serum of people with endometriosis.