Risk factors for adenomyosis

F Parazzini, Fabio Parazzini, Paolo Vercellini, P Vercellini, Stefania Panazza, S Panazza, Liliane Chatenoud, L Chatenoud, Silvia Oldani, S Oldani, Pier Giorgio Crosignani, P G Crosignani
Human Reproduction · 1997 · vol. 12(6) , pp. 1275–1279 · doi:10.1093/humrep/12.6.1275 · PMID:9222017 · W2125696112
article OA: bronze CC0 ⤵ 163 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that parity and spontaneous abortions were associated with an increased risk of adenomyosis, while smoking was associated with a decreased risk.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

In order to analyse risk factors for adenomyosis, 707 consecutive women who underwent hysterectomy between January 1993 and June 1994 at the Clinica Luigi Mangiagalli, Milan, Italy, were interviewed before surgery by trained physicians. Information on the presence of adenomyosis was obtained from pathologic records. Out of the 707 women, adenomyosis was identified in 150 subjects (21.2%). Women who smoked tended to be at decreased risk of the condition: in comparison with women who had never smoked, the risk for current smokers was 0.7 (0.3-1.3) and the risk decreased with number of cigarettes smoked per day, the odds ratios being 0.8 and 0.6 respectively in women reporting fewer than 10 and more than 10 cigarette smoked per day (chi2 trend 3.57, P = 0.06). The frequency of adenomyosis was higher in parous women: in comparison with nulliparae, the odds ratio of the disease were 1.8 [95% confidence interval (CI) 0.9-3.4] and 3.1 (95% CI 1.7-5.5) respectively in women reporting one and two or more births (chi2 trend 20.71, P < 0.01). Likewise, women reporting one or more spontaneous abortions had an odds ratio of 1.7 (95% CI 1.1-2.6) for adenomyosis, in comparison with those reporting no spontaneous abortion.

My notes (saved in your browser only)

Condition tags

mesh:D004715adenomyosis

MeSH descriptors

Endometriosis Abortion, Spontaneous Abortion, Spontaneous Adult Endometriosis Endometriosis Female Humans Hysterectomy Italy Italy Middle Aged Odds Ratio Parity Pregnancy Risk Factors Smoking

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (14)

Cited by (50)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:10:52.568893+00:00
License: CC0 · commercial use OK