Prognostic determinants for clinical pregnancy rate following IVF in women with ovarian endometriomas? A propensity score-matched retrospective cohort study

Y. Lynn Wang, Yuqing Zhang, X. Z. Wang, Na Duan, ZhenGao Sun, Ruihua Zhao, Yanyun Yin
In: Research Square · 2026 · doi:10.21203/rs.3.rs-8614148/v1 · W7126014125
preprint OA: green CC0
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study identified infertility type, obstetric history, and hormone levels as risk factors for ovarian endometriomas, and age, miscarriage history, COH protocols, and endometrioma size as predictors of IVF pregnancy success.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This propensity score-matched retrospective cohort study enrolled 248 transvaginal ultrasound–confirmed ovarian endometrioma (OMA) patients and 2,168 contemporaneous non-OMA IVF patients (adjusted to a 1:3 matched cohort) to identify factors associated with clinical pregnancy after IVF and to evaluate whether maximum OMA diameter predicts outcomes. After matching and multivariable logistic regression, OMA was independently associated with clinical pregnancy and early miscarriage rates, and factors linked to OMA and pregnancy included infertility type, obstetric history (abortions and cesareans), sex-hormone levels, and within the OMA subgroup age, miscarriage number, COH protocol, and maximum OMA diameter. The paper reports an integrated predictive model with AUC 0.857 and optimal predicted cutoffs of 32.5 years (age) and 21.25 mm (maximum OMA diameter). As a retrospective preprint, it is limited by its observational design and the specified exclusion of many comorbidities and prior treatments. This paper is centrally about endometriosis — it focuses specifically on ovarian endometriomas and how OMA characteristics and related risk factors predict IVF clinical pregnancy outcomes.

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