Endometriosis doubles odds for miscarriage in patients undergoing IVF or ICSI

Corinna Pallacks, Pallacks C, Jens Hirchenhain, Hirchenhain J, Jan-Steffen Krüssel, Krüssel JS, Tanja Fehm, Tanja N Fehm, Fehr D, Daniel Fehr
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 213 , pp. 33–38 · doi:10.1016/j.ejogrb.2017.04.008 · PMID:28419910 · W2604390640
article OA: closed CC0 ⤵ 17 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometriosis in women undergoing IVF or ICSI treatment for infertility was associated with a twofold increased risk of miscarriage.

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Abstract

ObjectiveTo identify and estimate the importance of risk factors on pregnancy loss until the end of the second trimester after clinical pregnancy was achieved by either in vitro fertilisation (IVF) or intra-cytoplasmic sperm injection (ICSI).Study designRetrospective cohort study including 588 cycles with fresh embryo transfers and 150 cycles with frozen-thawed embryo transfers using logistic regression.ResultsThe rate of miscarriages subsequent to a fresh embryo transfer was significantly increased by a diagnosis of endometriosis (p=0.02), as well as significantly influenced by the age of the female patient at the time of oocyte retrieval (p<0.01) and the serum level of testosterone (p=0.02). The time between freezing and thawing of the pronuclear stages for a frozen-thawed embryo transfer revealed a trend to a higher rate of miscarriages (p=0.06).ConclusionEndometriosis significantly decreases the chance of having a baby even with IVF or ICSI.

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Condition tags

endometriosis

MeSH descriptors

Abortion, Spontaneous Endometriosis Fertilization in Vitro Sperm Injections, Intracytoplasmic Abortion, Spontaneous Adult Age Factors Cohort Studies Cryopreservation Embryo Transfer Endometriosis Female Germany Germany Humans Male Middle Aged Oocyte Retrieval Oocytes Oocytes

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Cited by (17)

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