Endometrial causes of recurrent pregnancy losses: endometriosis, adenomyosis, and chronic endometritis

Paul Pirtea, Ettore Cicinelli, Cicinelli E, Rosalba De Nola, Dominique de Ziegler, de Ziegler D, Jean Marc Ayoubi, Ayoubi JM
Fertility and sterility · 2021 · vol. 115(3) , pp. 546–560 · doi:10.1016/j.fertnstert.2020.12.010 · PMID:33581856 · W3128542337
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This paper investigates endometriosis, adenomyosis, and chronic endometritis as potential endometrial factors contributing to recurrent pregnancy losses.

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Abstract

Chronic inflammatory processes affecting the endometrium, as encountered in endometriosis, adenomyosis, and chronic endometritis, alter endometrial receptivity. These disorders are associated with early pregnancy losses and possibly recurrent pregnancy losses (RPL). In the cases of endometriosis, other factors associated with the disease also are susceptible of causing miscarriages and possibly RPL, such as an impact of intrapelvic inflammatory processes affecting the oocyte and embryo in case of natural conception. Conversely these latter effects obviously are bypassed in case of assisted reproductive technology. Chronic inflammation of the endometrium in the condition known as chronic endometritis also causes early pregnancy losses and RPL with beneficial effects achieved when specific treatment is undertaken.

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Condition tags

mesh:D004716endometriosisadenomyosis

MeSH descriptors

Abortion, Habitual Adenomyosis Endometriosis Endometritis Endometrium Abortion, Habitual Abortion, Habitual Abortion, Habitual Adenomyosis Adenomyosis Adenomyosis Chronic Disease Embryo, Mammalian Embryo, Mammalian Embryo, Mammalian Endometriosis Endometriosis Endometriosis Endometritis Endometritis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc
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