Endometriosis and angiogenesis.

K May, Claudia Becker, C M Becker
Minerva ginecologica · 2008 · vol. 60(3) , pp. 245–54 · PMID:18547987 · W45959470
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review outlines basic and molecular mechanisms of angiogenesis and vasculogenesis in human endometrium and endometriotic implants, exploring their role in disease pathogenesis and potential therapeutic applications.

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Abstract

Endometriosis is a common gynecological condition, responsible for significant morbidity and social-economic impact. Although the condition has been recognized for many years, the underlying pathophysiology is poorly understood. In turn, this results in inadequate treatment and high recurrence rates. Various theories try to explain the presence of endometrial tissue outside the uterine cavity. However, none of them can explain all disease locations and appearances, and it is unclear how these fragments establish into endometriotic lesions. New vessel formation has long been recognized as a feature of endometriosis, often clearly visible at laparoscopy. Recent work has focused on identifying the role of vascularization in the pathogenesis of endometriosis, by allowing lesions to establish and grow. In this review the authors outline the basic mechanisms of angiogenesis and vasculogenesis in the human eutopic endometrium, and consider how this data can be applied to endometriotic implants. Furthermore, the authors discuss molecular mechanisms of angiogenesis and vasculogenesis, and how this may be used to therapeutic advantage in the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neovascularization, Pathologic Angiogenesis Inhibitors Angiogenesis Inhibitors Cyclooxygenase 2 Inhibitors Cyclooxygenase 2 Inhibitors Endometriosis Endometriosis Endostatins Endostatins Female Humans Laparoscopy Neovascularization, Pathologic Neovascularization, Pathologic Neovascularization, Physiologic Neovascularization, Physiologic Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (50)

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License: CC0 · commercial use OK