Resolvins RvD1 and 17(R)-RvD1 alleviate signs of inflammation in a rat model of endometriosis

Dmitrieva N, Natalia Dmitrieva, Gregory Suess, Suess G, Russell Shirley, Shirley R
Fertility and sterility · 2014 · vol. 102(4) , pp. 1191–1196 · doi:10.1016/j.fertnstert.2014.06.046 · PMID:25123641 · W2132555128
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Resolvins RvD1 and 17(R)-RvD1 were found to alleviate signs of inflammation in a rat model of endometriosis.

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Abstract

ObjectiveTo study the effects of two resolvins of D series, RvD1 and 17(R)-RvD1, on inflammatory signs associated with endometriosis (ENDO).DesignIn vivo research study.SettingResearch laboratory.Animal(s)Female Sprague-Dawley rats.Intervention(s)Intravenous or intraperitoneal injections of RvD1 (300 ng/kg) or 17(R)-RvD1 (300 and 900 ng/kg) in rats with surgically induced ENDO.Main outcome measure(s)Vascular permeability of ectopic endometrial growths was assessed by Evans Blue extravasation; vaginal hyperalgesia was assessed with telemetered visceromotor response.Result(s)Both resolvins, but not vehicle, significantly decreased vascular permeability in ectopic endometrial tissue. 17(R)-RvD1 also significantly alleviated severity of vaginal hyperalgesia.Conclusion(s)Our results suggest that RvD1 and 17(R)-RvD1 can be considered for further investigation of their therapeutic potential for treating ENDO.

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Condition tags

endometriosis

MeSH descriptors

Anti-Inflammatory Agents Docosahexaenoic Acids Endometriosis Animals Anti-Inflammatory Agents Anti-Inflammatory Agents Capillary Permeability Capillary Permeability Disease Models, Animal Docosahexaenoic Acids Docosahexaenoic Acids Endometriosis Endometriosis Endometriosis Female Hyperalgesia Hyperalgesia Hyperalgesia Injections, Intraperitoneal Injections, Intravenous

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