Overexpression of nerve growth factor in peritoneal fluid from women with endometriosis may promote neurite outgrowth in endometriotic lesions

Maria Luisa Barcena de Arellano, Maria Luisa Barcena, Barcena de Arellano ML, Julia Arnold, Arnold J, Julia T. Arnold, Vercellino F, Filiberto Vercellino, Vito Chiàntera, Vito Chiantera, Schneider A, Achim Schneider, Sylvia Mechsner
Fertility and sterility · 2010 · vol. 95(3) , pp. 1123–1126 · doi:10.1016/j.fertnstert.2010.10.023 · PMID:21047631 · W2005693586
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated the role of nerve growth factor (NGF) in peritoneal fluid from women with endometriosis and found it may promote neurite outgrowth within endometriotic lesions.

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Abstract

To investigate the role of the nerve growth factor (NGF) in the endometriosis-associated innervation in the development of endometriosis-associated symptoms, 41 peritoneal fluid samples (PF) from patients with surgically and histologically proven endometriosis and 20 PF from patients with other gynecologic conditions were analyzed with Western blot and a novel in vitro model using dorsal root ganglia (DRG) to show neuronal outgrowth; endometrial cells also were analyzed. The results suggest that the PF of endometriosis patients and endometriotic lesions have neurotropic properties, because the Western blot analysis and the cell culture stainings showed NGF expression, and the neurite outgrowth of DRG treated with PF of patients with endometriosis was significantly higher than when treated with PF of patients without endometriosis. Furthermore, blocking NGF with both anti-NGF and K252a leads to a significant decrease in neurite outgrowth.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_pain

MeSH descriptors

Ascitic Fluid Endometriosis Endometrium Nerve Growth Factor Neurites Animals Ascitic Fluid Blotting, Western Cells, Cultured Chick Embryo Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (50)

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