Endometriosis-Derived Thromboxane A2 Induces Neurite Outgrowth

Dingmin Yan, Xishi Liu, Sun-Wei Guo, Sun‐Wei Guo
Reproductive sciences (Thousand Oaks, Calif.) · 2016 · vol. 24(6) , pp. 829–835 · doi:10.1177/1933719116670037 · PMID:27688244 · W2524864746
article OA: closed CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

Endometriotic stromal cells secrete thromboxane A2, which was found to induce neurite outgrowth in primary sensory neurons in a concentration-dependent manner.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The paper investigated whether thromboxane A2 (TXA2), secreted by endometriotic stromal cells, promotes neurite outgrowth using primary rat dorsal root ganglion sensory neurons and human ectopic endometrial stromal cells (EESCs) derived from ovarian endometrioma tissues. Neurons were treated with U-46619, a TXA2 mimetic, or cocultured with EESC culture supernatants, with nerve growth factor as a positive control and ozagrel (a thromboxane synthase inhibitor) used to test TXA2 dependence. U-46619 increased neurite outgrowth and neurite end numbers in a concentration-dependent manner, and EESC supernatant induced neurite outgrowth to a level comparable to NGF while nearly 3-fold exceeding control; ozagrel pretreatment abolished part of this stimulatory effect. This study’s limitation is that it uses in vitro neuron assays and a stable TXA2 mimetic rather than measuring TXA2 directly in the coculture system. This paper is centrally about endometriosis — it shows endometriosis-derived stromal TXA2 drives neurite outgrowth, supporting mechanisms of endometriosis-associated hyperinnervation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Neurites Neuronal Outgrowth Ovarian Diseases Sensory Receptor Cells Thromboxane A2 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid Animals Dose-Response Relationship, Drug Endometriosis Female Ganglia, Spinal Ganglia, Spinal Humans Nerve Growth Factor Nerve Growth Factor Neurites Neuronal Outgrowth Ovarian Diseases

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