Peritoneal fluid 6‐keto‐prostaglandin FLα, thromboxane B2 in endometriosis and unexplained infertility

Aarne I. Koskimies, A I Koskimies, Koskimies AI, A Tenhunen, Tenhunen A, Anssi Tenhunen, Ylikorkala O, Olavi Mikorkala, O Ylikorkala
Acta obstetricia et gynecologica Scandinavica. Supplement · 1984 · vol. 63(S123) , pp. 19–21 · doi:10.3109/00016348409156975 · PMID:6594012 · W2015453662
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Radioimmunoassays of peritoneal fluid revealed elevated levels of 6-keto-prostaglandin F1 alpha and thromboxane B2 in women with endometriosis and unexplained infertility compared to controls.

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Abstract

To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGF1 alpha (a breakdown product of prostacyclin) and thromboxane B2 (T X B2) (a metabolite of T X A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endometriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGF1 alpha and T X B2 in PF were increased (p less than 0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGF1 alpha and T X B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1 alpha/T X B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T X A2 may be involved in infertility by interfering with tubal function.

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Condition tags

endometriosisinfertility

MeSH descriptors

6-Ketoprostaglandin F1 alpha Ascitic Fluid Endometriosis Infertility Thromboxane B2 Thromboxanes 6-Ketoprostaglandin F1 alpha Adult Ascitic Fluid Endometriosis Female Humans Infertility Male Thromboxane B2 Thromboxanes

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Cited by (11)

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