Peritoneal fluid 6-keto-prostaglandin F1 alpha, thromboxane B2 in endometriosis and unexplained infertility

Aarne I. Koskimies, A I Koskimies, Koskimies AI, A Tenhunen, Tenhunen A, Anssi Tenhunen, Ylikorkala O, Olavi Mikorkala, O Ylikorkala
Acta obstetricia et gynecologica Scandinavica. Supplement · 1984 · vol. 63(S123) , pp. 19–21 · doi:10.3109/00016348409156975 · PMID:6594012 · W2015453662
Observational OA: closed CC0 ⤵ 11 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Radioimmunoassays of peritoneal fluid revealed elevated levels of 6-keto-prostaglandin F1 alpha and thromboxane B2 in women with endometriosis and unexplained infertility compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To study peritoneal fluid (PF) prostaglandin (PG) in infertile women, 6-keto-PGF1 alpha (a breakdown product of prostacyclin) and thromboxane B2 (T X B2) (a metabolite of T X A2) were assayed with radio-immunoassays from PF samples collected at laparascopy from patients with endometriosis (n = 29), unexplained infertility (n = 13) and from women with normal pelvic organs (n = 25). The concentrations of 6-keto-PGF1 alpha and T X B2 in PF were increased (p less than 0.05) in endometriosis and unexplained infertility, as compared with the corresponding levels in the controls. In patients with endometriosis, both 6-keto-PGF1 alpha and T X B2 increases were related to the severity of the disease. There was no relationship between 6-keto-PGF1 alpha/T X B2 in PF, and day of menstrual cycle. It is suggested that endometriotic tissue and peritoneal macrophages may contribute to these prostanoids in PF. The smooth muscle activities of PF prostacyclin and T X A2 may be involved in infertility by interfering with tubal function.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

6-Ketoprostaglandin F1 alpha Ascitic Fluid Endometriosis Infertility Thromboxane B2 Thromboxanes 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Adult Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Female Female Humans Humans Infertility Infertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (14)

Cited by (11)

Source provenance

europepmc
last seen: 2026-10-21T06:16:17.486033+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:58:20.576574+00:00
License: CC0 · commercial use OK