PGE2 and PGF2α release by human peritoneal macrophages in endometriosis

Ulrich Karck, U. Karck, Karck U, F Reister, Frank Reister, Reister F, W Schäfer, Schäfer W, Wolfgang Schdfer, Zahradnik Hp, Hans-Peter Zahradnik, H. P. Zahradnik, M. Breckwoldt, Breckwoldt M
Prostaglandins · 1996 · vol. 51(1) , pp. 49–60 · doi:10.1016/0090-6980(95)00159-x · PMID:8900443 · W1979401373
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study investigated the release of PGE2 and PGF2α prostaglandins by human peritoneal macrophages, a key factor in endometriosis.

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Abstract

ObjectiveTo test for differences in the amount and activity of peritoneal macrophages present in the peritoneal fluid of women with, and without endometriosis using prostaglandin release by macrophages in culture as a marker.PatientsWomen of reproductive age undergoing laparoscopy for infertility or chronic pelvic pain with postoperative diagnosis of endometriosis and women undergoing laparoscopy for sterilization.MethodsPeritoneal fluid was aspirated during laparascopy, volume was recorded, macrophages were isolated via a Ficoll Paque gradient and kept in primary culture. PGE2 and PGF2 alpha release of the cells were measured before and after stimulation with zymosan.ResultsWomen with endometriosis had significantly more peritoneal macrophages than controls. Peritoneal macrophages of women with endometriosis released significantly more PGE2 than those of the control group: 8.4 +/- 2.0 versus 1.4 +/- 0.4 ng/ml/10(6) cells (mean +/- SEM, p = 0.0005) and PGF2 alpha: 10 +/- 4.3 (endometriosis) versus 1.8 +/- 0.4 (control) ng/ml/10(6) cells (mean +/- SEM, p = 0.045).ConclusionThere is a significant increase in the amount of prostaglandins released by peritoneal macrophages from women with endometriosis. These prostaglandins might alter uterine and tubal contractility, thereby affecting fertility.

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Condition tags

endometriosis

MeSH descriptors

Dinoprost Dinoprostone Endometriosis Macrophages, Peritoneal 6-Ketoprostaglandin F1 alpha 6-Ketoprostaglandin F1 alpha Adult Ascitic Fluid Ascitic Fluid Dinoprost Dinoprostone Dinoprostone Endometriosis Endometriosis Extracellular Space Female Humans Infertility Macrophages, Peritoneal Thromboxane B2

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (32)

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