H. P. Zahradnik

ObjectiveTo compare the effects of chlormadinone acetate (CMA), dienogest (DNG) and drospirenone (DRSP) on prostaglandin biosynthesis in a human endometrial explants model.Study designHuman endometrial explants obtained by aspiration curett…

To compare the effects of chlormadinone acetate (CMA), dienogest (DNG) and drospirenone (DRSP) on prostaglandin biosynthesis in a human endometrial explants model.

Cytochrome P450 metabolism of arachidonic acid (AA) was investigated in human peritoneal macrophages which play a central role in chronic pelvic diseases in women (for example in endometriosis). The formation of eicosanoids other than prost…

ObjectiveTo test for differences in the amount and activity of peritoneal macrophages present in the peritoneal fluid of women with, and without endometriosis using prostaglandin release by macrophages in culture as a marker.PatientsWomen o…

Primary dysmenorrhea occurs mostly in young women with a painful bleeding pattern. In a recent study, 72% of 19-year-old women had light, 19% had medium to severe, and 8% had severe symptoms. Secondary dysmenorrhea means pathological organi…

Six patients suffering from endometriosis (Acosta stages I to III) were treated by luteinizing hormone-releasing hormone agonists (LHRH-A). In 3 of the 6 patients buserelin (Hoechst AG, FRG) was subcutaneously infused using an osmotic minip…

Specimens of human myometrium (isthmus and fundus) freshly obtained at hysterectomy were immediately transferred in ice cold Tyrode solution and placed in superfusion chambers. Spontaneous contractions were recorded, the effluent of the myo…