Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression
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⤵ 22 in-corpus citations
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Lipopolysaccharide stimulation of endometriotic stromal cells increased their proliferation and invasion by upregulating cyclooxygenase-2 expression.
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Abstract
Lipopolysaccharide-enhanced cyclooxygenase 2 (COX-2) expression and prostaglandin E2 (PGE2) production were compared in endometriotic stromal cells (ESCs) and eutopic endometrial stromal cells. Lipopolysaccharide promotes the proliferation and invasion of ESCs via up-regulation of COX-2 and PGE2 expression, suggesting that pelvic inflammation may promote the progression of endometriosis.
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References (14)
- An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells via openalex
- A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis xenografts via antiangiogenic activity in severe combined immunodeficiency mice via openalex
- Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium via openalex
- Cyclooxygenase-2 overexpression in ovarian endometriomas is associated with higher risk of recurrence via openalex
- Cyclooxygenase-2 regulates survival, migration, and invasion of human endometriotic cells through multiple mechanisms via openalex
- Cyclooxygenase enzyme expression and E series prostaglandin receptor signalling are enhanced in heavy menstruation via openalex
- Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium via openalex
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- PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis via openalex
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- W2130131308 via openalex
- W2039274017 via openalex
- W6658226586 via openalex
Cited by (22)
- A Preliminary Investigation of the Roles of Endometrial Cells in Endometriosis Development via In Vitro and In Vivo Analyses 2024
- Associations between Exposure to Organochlorine Chemicals and Endometriosis: A Systematic Review of Experimental Studies and Integration of Epidemiological Evidence 2021
- Multiple Roles of Prostaglandin E2 Receptors in Female Reproduction 2020
- MicroRNA‑16 inhibits endometrial stromal cell migration and invasion through suppression of the inhibitor of nuclear factor‑κB kinase subunit β/nuclear factor‑κB pathway 2020
- Lipoxin A4 Suppresses IL-1β-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis 2019
- Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP-α in peritoneal macrophages 2019
- H2S promotes proliferation of endometrial stromal cells via activating the NF-κB pathway in endometriosis 2018
- Identification of microorganisms in vaginal swab and peritoneal fluid of women with endometriosis 2018
- New insights into the efficacy of SR-16234, a selective estrogen receptor modulator, on the growth of murine endometriosis-like lesions 2018
- New insights into the efficacy of SR-16234, a selective estrogen receptor modulator, on the growth of murine endometriosis-like lesions 2018
- Lipopolysaccharide promotes the development of murine endometriosis-like lesions via the nuclear factor-kappa B pathway 2017
- Enhanced cyclooxygenase-2 expression levels and metalloproteinase 2 and 9 activation by Hexachlorobenzene in human endometrial stromal cells 2016
- Anti-inflammatory, antiangiogenic, and apoptosis-inducing activity of DLBS1442, a bioactive fraction of Phaleria macrocarpa, in a RL95-2 cell line as a molecular model of endometriosis 2015
- Endometriosis: A Mysterious Disease 2014
- Parthenolide reduces cell proliferation and prostaglandin E2 [corrected] in human endometriotic stromal cells and inhibits development of endometriosis in the murine model 2013
- The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function 2013
- The role of NF-kappaB in endometriosis 2012
- Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway 2012
- Role of prostaglandin E2 in bacterial growth in women with endometriosis 2012
- Therapeutic potential of andrographolide for treating endometriosis 2012
- Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells 2010
- Resistin concentration is increased in the peritoneal fluid of women with endometriosis 2010
Source provenance
- europepmc
- last seen: 2026-10-11T09:27:45.537177+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:06:42.330992+00:00
- unpaywall
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