Apigenin inhibits tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells
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Apigenin was found to inhibit tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis in endometriotic stromal cells by inactivating NFκB.
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Abstract
Apigenin suppressed tumor necrosis factor α-induced cell proliferation and prostaglandin E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells in vitro. Apigenin reduced the mitogenic activity and inflammatory reaction in endometriotic stromal cells.
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References (22)
- Cyclooxygenase-2 Regulates Survival, Migration, and Invasion of Human Endometriotic Cells through Multiple Mechanisms via openalex
- Drug-induced apoptosis was markedly attenuated in endometriotic stromal cells via openalex
- Increased interleukin-6 levels in peritoneal fluid of infertile patients with active endometriosis via openalex
- Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression via openalex
- Lipopolysaccharide-promoted proliferation of endometriotic stromal cells via induction of tumor necrosis factor α and interleukin-8 expression via openalex
- Matrix Metalloproteinases and Endometriosis via openalex
- Pathogenetic Significance of Increased Levels of Interleukin-8 in the Peritoneal Fluid of Patients with Endometriosis via openalex
- PGE2 and PGF2α release by human peritoneal macrophages in endometriosis via openalex
- TAK1 activation for cytokine synthesis and proliferation of endometriotic cells via openalex
- Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex
- W2054633072 via openalex
- W1990218909 via openalex
- W2102715783 via openalex
- W2114168966 via openalex
- W1975813031 via openalex
- W2127092339 via openalex
- W2147980430 via openalex
- W1999757685 via openalex
- W1974661310 via openalex
- W2003241128 via openalex
- W2039274017 via openalex
- W2042642675 via openalex
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- Natural Products Targeting Oxidative Stress-Inflammation Crosstalk in Endometriosis 2026
- Multi-Target Modulation of Interconnected Pathogenetic Pathways by Natural Bioactive Compounds in Endometriosis 2026
- Phytochemicals Modulating Receptor Tyrosine Kinase Signaling Networks in Endometriosis 2026
- Polyphenols as Modulators of Oxidative Stress and Inflammation in Endometriosis: Molecular Mechanisms and Clinical Perspectives 2026
- Natural bioactive compounds and herbal medicines targeting common signaling pathways in endometriosis: mechanisms and therapeutic implications 2025
- Network-based pharmacology and experimental validation to explore the mechanism of action of the Jiawei Pentongling formula for the treatment of endometriosis-related pain 2024
- Intervention of Phytochemicals During Endometriosis and Their Conceivable Mechanisms 2023
- An Overview on the Conservative Management of Endometriosis from a Naturopathic Perspective: Phytochemicals and Medicinal Plants 2021
- Faculty Opinions recommendation of Polyphenols as a Diet Therapy Concept for Endometriosis-Current Opinion and Future Perspectives. 2021
- Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies† 2021
- Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives 2021
- Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies 2020
- The regression of endometriosis with glycosylated flavonoids isolated from Melilotus officinalis (L.) Pall. in an endometriosis rat model 2020
- Promising activity of Anthemis austriaca Jacq. on the endometriosis rat model and isolation of its active constituents 2019
- Lipopolysaccharide promotes the development of murine endometriosis‐like lesions via the nuclear factor‐kappa B pathway 2017
- The Cellular Inhibitor of Apoptosis Protein‐2 is a Possible Target of Novel Treatment for Endometriosis 2014
- The Cellular Inhibitor of Apoptosis Protein‐2 is a Possible Target of Novel Treatment for Endometriosis 2014
- Experimental endometriosis remission in rats treated with Achillea biebersteinii Afan.: histopathological evaluation and determination of cytokine levels 2014
- Apoptosis in Endometriosis 2014
- Parthenolide reduces cell proliferation and prostaglandin estradiol synthesis in human endometriotic stromal cells and inhibits development of endometriosis in the murine model 2013
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- last seen: 2026-06-10T17:14:06.276822+00:00
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