Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells

Kana Suou, Fuminori Taniguchi, Yukiko Tagashira, Tomoiki Kiyama, Naoki Terakawa, Tasuku Harada
Fertility and sterility · 2010 · vol. 95(4) , pp. 1518–1521 · doi:10.1016/j.fertnstert.2010.09.046 · PMID:21067731 · W1979549833
Lab / animal OA: bronze CC0 ⤵ 16 in-corpus citations
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Apigenin was found to inhibit tumor necrosis factor α–induced cell proliferation and prostaglandin E2 synthesis in endometriotic stromal cells by inactivating NFκB.

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Abstract

Apigenin suppressed tumor necrosis factor α-induced cell proliferation and prostaglandin E2 expression via the attenuation of nuclear factor κB pathway in endometriotic stromal cells in vitro. Apigenin reduced the mitogenic activity and inflammatory reaction in endometriotic stromal cells.

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MeSH descriptors

Apigenin Dinoprostone Endometrium Endometrium Growth Inhibitors NF-kappa B Tumor Necrosis Factor-alpha Adult Apigenin Cell Proliferation Cell Proliferation Cells, Cultured Dinoprostone Dinoprostone Endometrium Endometrium Female Growth Inhibitors Humans NF-kappa B

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