Lipopolysaccharide promotes the development of murine endometriosis‐like lesions via the nuclear factor‐kappa B pathway

Yukihiro Azuma, Fuminori Taniguchi, Kazuomi Nakamura, Kei Nagira, Yin Mon Khine, Tomoiki Kiyama, Takashi Uegaki, Masao Izawa, Tasuku Harada
American journal of reproductive immunology (New York, N.Y. : 1989) · 2017 · vol. 77(4) · doi:10.1111/aji.12631 · PMID:28138997 · W2584002740
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Lipopolysaccharide administration increased the number, size, and inflammatory marker expression of endometriosis-like lesions in mice, which was reversed by an NF-κB inhibitor.

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Abstract

PROBLEM: Is lipopolysaccharide (LPS) involved in the development of endometriosis? METHOD OF STUDY: BALB/c mice (n=69) were used for the murine endometriosis model. Mice with surgically induced endometriosis were injected with LPS intraperitoneally. After 4 weeks of LPS injections with or without the nuclear factor-kappa B (NF-κB) inhibitor, the extent of endometriosis-like lesions was evaluated. Expression of inflammatory factors in the implants was evaluated using real-time RT-PCR. Cell proliferation, angiogenic activity, inflammation, and NF-κB phosphorylation were assessed by immunohistochemical staining. RESULTS: Lipopolysaccharide increased total number, size, and mRNA expression of Ptgs-2, Vegf, Ccl-2, and Il-6 in endometriosis-like lesions. LPS also increased the percentage of Ki67-positive cells and enhanced the intensity and rate of positive cells of CD3, F4/80, and PECAM. Intense expression of phospho-NF-κB p65 after LPS administration was observed. Treatment with the NF-kB inhibitor negated these LPS-induced effects. CONCLUSION: LPS-induced pelvic inflammation status enhanced the development of murine endometriosis-like lesions via NF-κB pathway.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Lipopolysaccharides NF-kappa B Signal Transduction Animals Disease Models, Animal Endometriosis Endometriosis Female Immunohistochemistry Inflammation Inflammation Inflammation Inflammation Lipopolysaccharides Mice Mice, Inbred BALB C NF-kappa B Real-Time Polymerase Chain Reaction Signal Transduction

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